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Vit D-genetic difference article

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mainsailset View Drop Down
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    Posted: Jun 09 2010 at 11:14pm
This is fascinating and first thought is how it relates to BRCA status
 
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 10 2010 at 3:40am
Very interesting article. The vitamin D deficiency may be more complex than we thought.
I'm glad there is more research into D and it's important role.

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jun 10 2010 at 9:29am
Are you back? How did trip go??
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote dmwolf Quote  Post ReplyReply Direct Link To This Post Posted: Jun 10 2010 at 9:35am
Interesting.  This illustrates the issue of potentially confusing correlation with causality.  We are all busy trying to increase our vitD levels, thinking that there is a causal link between vitD blood levels and cancer.  But it might just be association.  It might be that whatever gene locus predisposes us to low vitD levels also predisposes us to cancer.  Taking a lot of vitD might not fix whatever the problem is that these gene mutations are causing leading to greater risk of breast cancer.  Then again, it might be causal.  It could be that gene variant -> low vitD -> increase risk.  Right now, there's no way of knowing which it is.    To directly test, you'd need a study where they look at people with the gene variation and split it in half, giving one group a lot of vitD and the other a placebo.  Then we'd see which it is.  Actually, you'd want a bigger study with four groups: people with and without the mutations, and within each, subgroups supplemented or not.   Then you'd get the whole story.

DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jun 10 2010 at 2:34pm

Denise, yes, agreed. I am happily startled that D is getting such a rush of attention. Hopefully, someone with some grant money to spare (hahahaha!) will read your mind and initiate a study as you proposed.

I find it interesting that some of the same things keep cropping up, such as D & stress. I'm constantly wondering whether the outside chemicals we are now stuffed with don't just interfere with our metabolisms, artifically damage our genes but also deplete our ability to repair and that we are the victims (hate that word) of a perfect storm of physical ingredients gone amuck.
 
Personally, I have little doubt that someday we'll find that the D & cancer (and all the other diseases it seems to be associated with) are somehow sharing the same family tree and whether D is the canary in the mineshaft or if cancer is, they're both coughing like mad.
 
Here's hoping for more interest and studies.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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