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Triple negative or HER2 positive confusion

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Kiannwhite View Drop Down
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    Posted: May 29 2015 at 4:33am


My mother was diagnosed with stage 4 breast cancer this past September at 36 years old. Since then, she's had 2 biopsies done. The first from her breast (which the cancer is outside of) this biopsy came back with a 2 and they did a fish test coming back triple negative. After this she had a lymph node biopsy, this time it came back the same thing, so her oncologist sent in for a fish which came back her2+, but a few days after he told us the news, he said that it was a mistake. During this time for 3 months she was on abraxane which seemed to work but stopped after 3 months. Her cancer grew rapidly and her live mets were growing so big that her liver was pressing on ribs. So now she is at a new oncologist and she is saying she always goes with a positive, saying she's her2+... Right now my mom is on herceptin, perjeta and taxotere. We have not had a pet test yet but her cancer in her breast has shrunk visually. My mom is brca1- and brca-2 negative with no tumor markers. Her ki67 from her breast biopsy was 97%, her lymph node biopsy was 79%. Her breast and liver have nercrosing, with her breast cancer coming outside of her breast. Her first breast biopsy came back HER 2+ fish came back her2- ratio 1.11 unamplified. Lhymp node biopsy came back HER 1+ Fish came back HER2+ ratio 3.2. Her first doctor said she was Triple negative due to brca, aggressiveness, and chemotherapy testing. She now has a new oncologist and she said she always goes with the positive and is treating her for her2+ which she is vid ally responding to and we have to wait for PET. She was on abraxane for 3 months and never had these kinds of changed. Should she get a liver biopsy or anymore tests?? Any advice or opinions and expierences help thanks so much guys!
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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 29 2015 at 12:48pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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