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TNBC Target Found?

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123Donna View Drop Down
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    Posted: Aug 14 2016 at 10:14am

Triple-negative breast cancer target is found

UC Berkeley researchers have found a long-elusive Achilles’ heel within “triple-negative” breast tumors, a common type of breast cancer that is difficult to treat. The scientists then used a drug-like molecule to successfully target this vulnerability, killing cancer cells in the lab and shrinking tumors in mice.

“We were looking for targets that drive cancer metabolism in triple-negative breast cancer, and we found one that was very specific to this type of cancer,” said Daniel K. Nomura, an associate professor of chemistry and of nutritional sciences and toxicology at UC Berkeley and senior author for the study, which is published online ahead of print on May 12 in Cell Chemical Biology.

Click on the link to read the entire article:

http://news.berkeley.edu/2016/05/12/triple-negative-breast-cancer-target-is-found/

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
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mainsailset View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Aug 14 2016 at 3:24pm
Thanks so much for posting this Donna. It looks like a two-fer in that UCB not only discovered a target but also an innovative procedure that can be expanded to discover targets for other tumors.

Sounds like this is in the very beginnings of recognition so a long long ways to go before human trials are set into motion. May this receive more and more attention!
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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