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Reusing parp inhibitor

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rstar View Drop Down
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    Posted: Mar 09 2017 at 5:45pm
Hi there, 

My mom has been taking the parp inhibitor Talazoparib in a clinical trial for 11 months and progressed for a single tumor only that constantly grew. Xeloda did absolutely nothing and the side effects on Gemcarbo were too much!  I was wondering if using another parp inhibitor from a different company (like Olaparib) would benefit her? I've read somewhere that parp inhibition is different between these drugs so i'm guessing it's worth giving it a try. Any thoughts?
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gordon15 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 10 2017 at 3:15pm
I'm not familiar with this drug, I saw this:
http://www.medscape.org/viewarticle/711369

sorry if this isn't very helpful, my wife is seeing a doctor at UCSanDiego and she has a good oncologist at Scripps/La Jolla/San Diego, his name is Sinclair, and he is pretty "blunt" on what is going to work or not, James Sinclair.

wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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gordon15 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 10 2017 at 3:23pm
Sorry I don't have an answer for you, I saw this article...
http://www.onclive.com/web-exclusives/role-of-parp-inhibitors-evolving-in-triplenegative-breast-cancer

it keeps saying "informative" which in my mind means not conclusive...so I am just pointing hat out, when I read clinical trials' results, I read between the lines, and it's best to ask your oncologist, if this has validity...

We are in San Diego, and I know we have a good oncologist and surgeon, Oncologist is Dr. James Sinclair,/Scripps/  he has been very straight with us, whether any new drugs are promising...
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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