Go To Main TNBC Website


  New Posts New Posts RSS Feed - Researchers May Have Uncovered a Therapy for TNBC
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Researchers May Have Uncovered a Therapy for TNBC

 Post Reply Post Reply
Author
123Donna View Drop Down
Senior Member
Senior Member
Avatar

Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 12886
Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Topic: Researchers May Have Uncovered a Therapy for TNBC
    Posted: Jun 20 2018 at 7:36pm

The answer to triple-negative breast cancer?

How computational geeks may have uncovered a therapy for a deadly disease


Summary:
Researchers have developed a computer program which has revealed a previously unknown combination of drugs that may be the answer to Triple Negative Breast Cancer (TNBC), using genetic and treatment data from TNBC cells grown in labs and from hundreds of patients world-wide. Importantly researchers can tell, by inputting patients' genomic and proteomic information into their computer model, who may benefit from this drug combination or not -- saving precious time.

https://www.sciencedaily.com/releases/2018/06/180619141342.htm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Back to Top
123Donna View Drop Down
Senior Member
Senior Member
Avatar

Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 12886
Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 20 2018 at 7:37pm

Triple-negative breast cancer has no targeted drug therapy and, as such, the only hope for these patients is chemotherapy. Triple-negative breast cancer is aggressive and deadly. Patients are currently treated by chemotherapy but there is no guarantee of success -- and unfortunately, for those that chemotherapy does not work, the survival rate remains only 12 months.

Doctors are turning to combination therapies -- cocktails of drugs -- in an effort to kill the cancer. However there is no reliable way to predict which combinations, amongst hundreds, will work (and work quickly) for an individual patient with triple-negative breast cancer.

Monash researchers have used genetic and treatment data from triple-negative cancer cells grown in the lab and from hundreds of patients world-wide to develop a computer program, which has revealed a previously unknown combination of drugs that may be the answer to the disease. Writing in the journal PLOS Computational Biology, Dr Lan Nguyen from the Monash Biomedicine Discovery Institute and his team believe the computer model will eventually become an app that clinicians can use to match the best combinations of drugs for individual patients who present with the disease.

Triple-negative breast cancer cells can develop resistance to a single targeted drug within days, sometimes hours -- largely by re-routing the signaling pathways within the cells.

"It's similar to when there's a car accident, and the traffic manages to re-route itself around it without causing gridlock," Dr Nguyen said.

"But how exactly these cancer cells find new routes to avoid the drug effect remains largely unknown," he added.

The Monash team, in collaboration with colleagues at the Weizmann Institute in Israel, have characterised a key signaling network that drives the growth of triple-negative breast cancers and developed a computer model that can predict how the network re-routes in response to a particular drug agent.

This new model and its predictions then allowed them to rank various combinations of drugs as to which are the most likely to defeat the cancer, by blocking the new route undertaken by the cancer cells. Using data from The Cancer Genome Atlas, a database of cancer genes and patient histories run by the National Institutes of Health in the US, the researchers tested their league table of drug combinations to determine their success in people who had survived triple-negative breast cancer.

Importantly they can tell, by examining a patient's genomic and proteomic information and inputting this information into their computer model, who may benefit from this drug combination and who may not -- so that precious time is not lost in treating a patient with the wrong drugs.

The researchers found a previously unknown combination of two drugs that the model predicts could be successful in treating this previously untreatable disease, according to Dr Sungyoung Shin, first author on the paper.

"We hope to have this new combination in clinical trials in two to five years," Dr Nguyen said.

The computer model can be adapted and used to determine effective drug combinations for other serious cancers, such as lung and melanoma, where network re-routing in order evade drug effect has been observed, he added.

The study, co-led by Dr Nguyen (Monash) and Professor Sima Lev (Weizmann), provides an important advancement towards development of personalised treatment for cancer patients.

https://www.sciencedaily.com/releases/2018/06/180619141342.htm


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Back to Top
parrynd1 View Drop Down
Newbie
Newbie
Avatar

Joined: Feb 28 2017
Location: California
Status: Offline
Points: 36
Post Options Post Options   Thanks (0) Thanks(0)   Quote parrynd1 Quote  Post ReplyReply Direct Link To This Post Posted: Jun 21 2018 at 1:39pm
I’ll be keeping an eye on where this leads for the next few years, thanks Donna!
Dx TN IDC 9/016 Age 28, Stage 3c, Grade 3, 4.5cm, .7cm, 1/5 Nodes, BRCA -, KI-67 >90%, 6/6 I-Spy 2, 4/4 rounds DD A/C, Lumpectomy w/reduction, 3 nodes removed, weekly Taxol/Carb1/12
Back to Top
Elisa View Drop Down
Newbie
Newbie
Avatar

Joined: Dec 31 2017
Location: Denmark
Status: Offline
Points: 8
Post Options Post Options   Thanks (0) Thanks(0)   Quote Elisa Quote  Post ReplyReply Direct Link To This Post Posted: Jun 22 2018 at 6:59am
This is very interesting, thank you Donna
Back to Top
 Post Reply Post Reply
  Share Topic   

Forum Jump Forum Permissions View Drop Down

Forum Software by Web Wiz Forums® version 11.05
Copyright ©2001-2016 Web Wiz Ltd.