Go To Main TNBC Website


  New Posts New Posts RSS Feed - Reparixin + Taxol Study
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Reparixin + Taxol Study

 Post Reply Post Reply
Author
atlhoosier View Drop Down
Groupie
Groupie
Avatar

Joined: Feb 18 2014
Status: Offline
Points: 44
Post Options Post Options   Thanks (0) Thanks(0)   Quote atlhoosier Quote  Post ReplyReply Direct Link To This Post Topic: Reparixin + Taxol Study
    Posted: Jun 06 2017 at 1:18pm
Hi everyone.  I am newly diagnosed stage 4 and was wondering if anyone has participated in a trial that combines taxol with reparixin?  It's fairly new, randomized and in phase 2.  I was wondering how you are responding and any side effects.  Thank you!
DX Jan 2014, 37yo
TNBC, Stage 2A, 4 tumors, BMX Aug 2014, clear margins

2017 - Mets to lung (single nodule) & sacrum
1st line(current): clinical study w/ taxol & reparixin (may be placebo)
Back to Top
123Donna View Drop Down
Senior Member
Senior Member
Avatar

Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 12834
Post Options Post Options   Thanks (1) Thanks(1)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 07 2017 at 8:05am
I'm sorry you are dealing with a recurrence.  Where did it metastasize?  I don't have any information on this study, but there was this release of the results of hte Phase 1B study.



These are from older threads:

Reparixin is a CXCR1/2 inhibitor with a low molecular weight that in experimental studies has been shown to be able to reduce cancer stem cells if administered alone or in association with chemotherapy with medicines of the taxane family. With reparixin, the aim is to inhibit the activity of the "driving force" of the inflammation in order to keep under control the development of breast cancer stem cells and, potentially, other neoplasia as well, in addition to altering the microenvironment that allows their development.

SAN ANTONIODecember 11, 2014 /PRNewswire/ --

Other immunotherapy approaches

“Our immunotherapy studies have moved from just vaccines to include checkpoint inhibitors and other immunotherapy strategies,” Dr. Mittendorf said. “And as an institution, we have the opportunity to do more.”

For example, Dr. Ibrahim is the principal investigator at MD Anderson for an ongoing multi-institutional trial of the oral immunostimulant indoximod with taxane-based chemotherapy for patients with HER2-negative metastatic breast cancer. Indoximod inhibits the indoleamine 2,3-dioxygenase pathway, which suppresses T cell activity.

Also under investigation are agents that block the action of interleukin-8 (CXCL8), which has an immunomodulatory effect and is associated with breast cancer growth and metastasis. A trial of one such agent, reparixin, which binds to the CXCL8 receptor CXCR1, is underway at MD Anderson and other institutions.

Preclinical studies of promising therapies also are underway. For example, Dr. Mittendorf said, Laurence Cooper, M.D., Ph.D., a professor in the Division of Pediatrics, is investigating the use of T cells modified with chimeric antigen receptors (see â€œSleeping Beauty” Technique Modifies T Cells to Treat B Cell MalignanciesOncoLog, May 2014) against triple-negative breast cancer.

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Back to Top
atlhoosier View Drop Down
Groupie
Groupie
Avatar

Joined: Feb 18 2014
Status: Offline
Points: 44
Post Options Post Options   Thanks (0) Thanks(0)   Quote atlhoosier Quote  Post ReplyReply Direct Link To This Post Posted: Jun 07 2017 at 10:49am
Hi Donna, I have a single nodule on my right middle lung, and also sacrum.  :(
DX Jan 2014, 37yo
TNBC, Stage 2A, 4 tumors, BMX Aug 2014, clear margins

2017 - Mets to lung (single nodule) & sacrum
1st line(current): clinical study w/ taxol & reparixin (may be placebo)
Back to Top
123Donna View Drop Down
Senior Member
Senior Member
Avatar

Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 12834
Post Options Post Options   Thanks (1) Thanks(1)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 07 2017 at 7:47pm
I hope you will hear from others that might be in this trial.  If you enter the trial, please keep us posted on how you are doing.  Wishing you the best and you get to NED!

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Back to Top
gordon15 View Drop Down
Senior Member
Senior Member


Joined: Jun 22 2015
Location: San Diego CA
Status: Offline
Points: 779
Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Jun 07 2017 at 9:01pm
I found this

http://www.publicnow.com/view/D355F66930C80E4A34FB756E0EEF1EE5845D9B77?2016-12-09-15:30:25+00:00-xxx2658

not finding much info on Reparixin

Edited by gordon15 - Jun 07 2017 at 9:03pm
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
Back to Top
atlhoosier View Drop Down
Groupie
Groupie
Avatar

Joined: Feb 18 2014
Status: Offline
Points: 44
Post Options Post Options   Thanks (1) Thanks(1)   Quote atlhoosier Quote  Post ReplyReply Direct Link To This Post Posted: Sep 15 2017 at 10:39am
Just wanted to post an update if anyone reads this.  After the first cycle of 2 months, my results did show that the tumor has shrunk from 13 x 10 mm to 11 x 7 mm!
DX Jan 2014, 37yo
TNBC, Stage 2A, 4 tumors, BMX Aug 2014, clear margins

2017 - Mets to lung (single nodule) & sacrum
1st line(current): clinical study w/ taxol & reparixin (may be placebo)
Back to Top
Kellyless View Drop Down
Senior Member
Senior Member


Joined: Jun 18 2009
Location: Dallas, Texas
Status: Offline
Points: 928
Post Options Post Options   Thanks (1) Thanks(1)   Quote Kellyless Quote  Post ReplyReply Direct Link To This Post Posted: Sep 16 2017 at 2:11pm
Congratulations! How are you doing with the side effects?
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/17 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!
Back to Top
gordon15 View Drop Down
Senior Member
Senior Member


Joined: Jun 22 2015
Location: San Diego CA
Status: Offline
Points: 779
Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Sep 17 2017 at 7:54pm
Thanks for the update!
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
Back to Top
atlhoosier View Drop Down
Groupie
Groupie
Avatar

Joined: Feb 18 2014
Status: Offline
Points: 44
Post Options Post Options   Thanks (0) Thanks(0)   Quote atlhoosier Quote  Post ReplyReply Direct Link To This Post Posted: Sep 17 2017 at 11:44pm
I'm doing fine...maybe decent is a better word. I think most of my side effects sten from the taxol--just the usual stuff--hair loss, neuropathy (not too bad), weight gain. Sometimes I'm a little gassy right after I take the study drug, but that's it.
DX Jan 2014, 37yo
TNBC, Stage 2A, 4 tumors, BMX Aug 2014, clear margins

2017 - Mets to lung (single nodule) & sacrum
1st line(current): clinical study w/ taxol & reparixin (may be placebo)
Back to Top
 Post Reply Post Reply
  Share Topic   

Forum Jump Forum Permissions View Drop Down

Forum Software by Web Wiz Forums® version 11.05
Copyright ©2001-2016 Web Wiz Ltd.