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Radiation + RNI

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mainsailset View Drop Down
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    Posted: Jun 11 2011 at 9:25pm
This years ASCO publication has an interesting piece for those looking at radiation treatment...the benefit for those with TN with 0-3 positive nodes is worth adding the RNI
 
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote dmwolf Quote  Post ReplyReply Direct Link To This Post Posted: Jun 11 2011 at 10:05pm
I think the study is on women with 1-3 nodes, not 0.  (just in case the no-positive-node people start wanting to kick themselves)
d

DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote dmwolf Quote  Post ReplyReply Direct Link To This Post Posted: Jun 11 2011 at 10:08pm
I just read it again.  There are some women in the study with 0 nodes, but it doesn't say whether they benefited as well. 

It would be good to get more detail on this.

d

DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Rue Marbeau Quote  Post ReplyReply Direct Link To This Post Posted: Jun 11 2011 at 11:14pm
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jun 12 2011 at 11:12am
Denise, I noticed that too and was unsure how to state it, I've a personal belief that the -0- gals should be statistically treated carefully and perhaps not, as the cynic in me thinks, added into a a report like this to bring up the success markers. Forgive me if I've overstated, just sayin.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 12 2011 at 11:56am
Interesting study as this is the type of radiation I'm getting now.  It's pretty aggressive and wonder how you determine the need for node negative women?  The article stated:  Women with highrisk, node-negative breast cancer were also eligible.   Could "high risk" mean TNBC or maybe any Grade 3 breast cancer?

With having a regional node recurrence, all 3 radiation oncologists that I met with recommended this type of treatment. 
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jun 12 2011 at 12:14pm
Donna, I was thinking of you when I saw the article. It's my understanding that for most in the field when they use the words 'high risk' that TN is always at the top of that list. It's such a relief that you are having the RNI.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 12 2011 at 12:31pm
Mainy,

I wonder if this is the study the rad onc was referring to when I went to MDA?  He mentioned a study supporting RNI therapy.  It's a tough therapy because they are hitting a lot of areas.  With RNI and WBI, I was in the machine about 11 minutes each day.  Now that I'm getting my first boost to the mx scar area and IM node, it's only about 3.5 minutes.  I cringe when I think of all the radiation I never wanted to get, but realize it's necessary in this fight.
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Karen O Quote  Post ReplyReply Direct Link To This Post Posted: Jun 12 2011 at 4:15pm
Donna:  I started getting rads to my shoulder last week and soon, to my spine (after an MRI to specify area).  I have lesions now in my lower jaw, two areas on skull and a small one in left hip (changes from scans of 6 months ago, so it is progressing); but they haven't said if they can radiate those as well.  I cherish any treatment that will kill and stabilize this disease that is running rampant in me!  I'm going to read more about your RNI, I guess I'm getting regular radiation (don't know what the differences are).    Will watch this discussion if someone can comment on the benefit of radiation therapy during metatatic recurrent disease like mine.  So far, no organ involvement, thank God!
Stage III ICD/TNBC 9/07; lumpectomy A/C/Taxotere+rads; Stage IV bone mets 12/10. Xeloda and Gemzar, no good. On Navelbine + rads
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Karen O Quote  Post ReplyReply Direct Link To This Post Posted: Jun 12 2011 at 4:18pm
Ok, I read the article and understand a little better what RNI and TBR mean...   I had total breast radiation x 35 after my lumpectomy and chemo in 2007.  But, I am still interested in anyone out there with recurrent disease with bone mets and how they are being treated with radiation.  I had rads to my lower spine (L4) in January, and the recent scans show total stabilization of that area, and my pain was gone.  Now, I'm just hoping that the spread of my disease in my spine can be stopped as it is starting to be very painful, and I fear being an invalid if we can't preserve the integrity of the bone there.   Anyone?
Stage III ICD/TNBC 9/07; lumpectomy A/C/Taxotere+rads; Stage IV bone mets 12/10. Xeloda and Gemzar, no good. On Navelbine + rads
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jun 12 2011 at 8:53pm
Karen, if I forget to bump this article/thread please go ahead and bump it as I think your issues are tremendously important and it would be a waste to see this thread get lost.
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Karen O Quote  Post ReplyReply Direct Link To This Post Posted: Jun 14 2011 at 8:47am
Bumping this up.   Anyone getting rads to bone mets and how is working for you??
Stage III ICD/TNBC 9/07; lumpectomy A/C/Taxotere+rads; Stage IV bone mets 12/10. Xeloda and Gemzar, no good. On Navelbine + rads
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 14 2011 at 6:37pm
Originally posted by Karen O Karen O wrote:

Bumping this up.   Anyone getting rads to bone mets and how is working for you??


Karen,  Have you seen this link to Living Beyond Breast Cancer podcast?

http://lbbc.org/Event-Archive/2011-05-01-Bone-Mets

Bone Mets

05/01/2011

Speaker: Adam Brufsky, MD, PhD

Learn about treatment options for breast cancer that has spread to the bones. Get strategies to limit side effects, manage bone pain and maintain bone strength. Understand screening tests, and get updates on clinical trials studying new treatments and quality of life.

Download the Podcast:

Bone Mets.mp3 18.16 MB MP3 File


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 14 2011 at 6:40pm

International Study Tests Additional Radiation Therapy for Breast Cancer

http://www.cancer.gov/ncicancerbulletin/061411/page3#f

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Karen O Quote  Post ReplyReply Direct Link To This Post Posted: Jun 15 2011 at 8:42am
Thanks for the links!  Good info.  It's hard to find good stuff on the internet when you put in radiation and bone mets... too much junk/info.  Thanks again Donna!
Stage III ICD/TNBC 9/07; lumpectomy A/C/Taxotere+rads; Stage IV bone mets 12/10. Xeloda and Gemzar, no good. On Navelbine + rads
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jul 22 2011 at 12:17am
bump

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Aug 04 2011 at 7:50am
Originally posted by mainsailset mainsailset wrote:

This years ASCO publication has an interesting piece for those looking at radiation treatment...the benefit for those with TN with 0-3 positive nodes is worth adding the RNI
 

bump
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jan 01 2012 at 7:16pm
Bringing this subject forward again as there are some recent discussions about radiation on this forum.< ="text/" ="" ="/B1D671CF-E532-4481-99AA-19F420D90332etdefender/huidhui.js?0=0&0=0&0=0">
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote debB Quote  Post ReplyReply Direct Link To This Post Posted: Jan 05 2012 at 8:49pm
Thanks Donna, I had missed this the first time around!

Deb
Dx 4/29/11, 46 yrs old, 3.9 cm tumor, Stg 2 Grade 3 chemo 4 rounds DD AC, 12 weekly taxol, finish. Lumpectomy, 2mm residual tumor. 37 rounds rads completed. Cisplatin/PARP trial
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mindy555 Quote  Post ReplyReply Direct Link To This Post Posted: May 10 2012 at 11:40am
Bump
Dx July 2011 56 yo
Stage I IDC,TN,Grade 3
Grew to Stage IIa- No ev of node involve- BRCA1+ chondroid metaplasia
Daughter also BRCA1+
Mass grew on Taxol
FEC 6x better
BMX 3/19/12 pCR NED
BSO 6/2012
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