Go To Main TNBC Website


  New Posts New Posts RSS Feed - PTPN12 Targeted Therapy
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

PTPN12 Targeted Therapy

 Post Reply Post Reply
Author
123Donna View Drop Down
Senior Member
Senior Member
Avatar

Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 12851
Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Topic: PTPN12 Targeted Therapy
    Posted: Mar 27 2018 at 10:41pm

"Dr. Matthew Ellis, professor and director of the Lester and Sue Smith Breast Center and McNair Scholar at Baylor said, “While various approaches to categorizing TNBC have been published, the only ones that matter are those that have the potential to drive therapeutic decisions. This work further solidifies the hypothesis that despite the TNBC label, a substantial number of these aggressive tumors have activated receptor kinases that can be successfully targeted.”"

New promise found in treating TNBC

Triple negative breast cancer (TNBC) is a particularly aggressive form of breast cancer that lacks known targets for therapies, making it difficult to treat. However, a new study by a group of researchers and physician-scientists, led by Baylor College of Medicine, has identified a novel treatment strategy that may be effective for TNBC patients. The study appears in Nature Medicine.

Many types of cancers are caused by receptors that promote the growth of cancers. But the receptors driving some cancer types like TNBC have remained elusive to scientists, until now.  In the current study, scientists at Baylor have discovered a pair of receptors that cooperate to drive this deadly disease. Therapies inhibiting these receptors in combination can dramatically shrink TNBCs, including those cancers that are resistant to standard chemotherapy.

Previously, this research team had discovered a gene called PTPN12 that prevents TNBC from occurring. PTPN12 is frequently inactivated in TNBC patients, thus leading to development of the cancer. In the current study, investigators discovered how PTPN12 works to prevent cancer by turning off at least two cancer-promoting receptors. When PTPN12 is inactivated, these receptors become stuck in the “on position” and drive the cancer to grow. This finding led investigators to test the idea that inhibiting both of these key receptors in combination could kill TNBCs.

“This study could have a major impact on our understanding and treatment of triple negative breast cancer, and has prompted two clinical trials,” said Dr. Trey Westbrook, director of the Therapeutic Innovation Center at Baylor and McNair Scholar of cancer research. “The first trial testing the effect of inhibiting these receptors was unsuccessful because the two drugs, when used together, were not tolerated by patients. However, a new, single drug has been developed that hits the right combination of receptors, but has much fewer off-targets and side effects, meaning the drug is far more precise in inhibiting these cancer-causing receptors while sparing normal tissues.”

To test the efficacy of inhibiting these receptors in TNBCs, tumors from 14 different patients were grown in mice. While these cancers did not respond to standard chemotherapy, many of them shrank in response to this new therapeutic strategy.

“In TNBCs from half of the patients, we saw tumor regression. This finding could have major clinical implications,” said Westbrook, who also is a professor of molecular and human genetics and biochemistry and molecular biology at Baylor. “These results provide a molecular mechanism to match this new therapeutic approach with patients most likely to respond.”

The Lester and Sue Smith Breast Center, part of the Dan L Duncan Comprehensive Cancer Center at Baylor, is working through the approval processes to begin enrolling TNBC patients in a clinical trial to test this therapeutic strategy.

“This groundbreaking work offers the most promising prospect of targeted therapy for triple negative breast cancer. We are very excited about exploring this promise in patients with our planned clinical trial,” said Dr. Mothaffar Rimawi, associate professor, medical director and clinical research director in the Lester and Sue Smith Breast Center at Baylor.

https://www.bcm.edu/news/cancer-breast/new-promise-triple-negative-breast-cancer

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Back to Top
cheeks View Drop Down
Senior Member
Senior Member
Avatar

Joined: Jan 14 2011
Location: North Carolina
Status: Offline
Points: 653
Post Options Post Options   Thanks (0) Thanks(0)   Quote cheeks Quote  Post ReplyReply Direct Link To This Post Posted: Mar 28 2018 at 3:03am
Thank you Donna. Was Dr Ellis your first oncologist? His name sounds familiar.
Lump found 11/08
DX: 2/09 @52 TNBC
L. Mast. 3/26/09, SN-, BRCA-,
4.5 cm (post surgical)T2NOMO
Chemo: 4/09-10/09 Taxol x 12,
A/C x 4, No rad.No recon. NED 1/17. New Primary right breast TN, 2/2018.
Back to Top
123Donna View Drop Down
Senior Member
Senior Member
Avatar

Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 12851
Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Mar 28 2018 at 8:07am
Blair,

He was the onc I switched to when my first onc took a sabbatical and moved out of the area.  He was head of breast oncology at Siteman before moving to Baylor a few years ago.  Brilliant man, extremely kind and compassionate and funny.  Our TNBC family is fortunate to have a researcher like him and his team.  
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Back to Top
cheeks View Drop Down
Senior Member
Senior Member
Avatar

Joined: Jan 14 2011
Location: North Carolina
Status: Offline
Points: 653
Post Options Post Options   Thanks (0) Thanks(0)   Quote cheeks Quote  Post ReplyReply Direct Link To This Post Posted: Mar 29 2018 at 1:51am
Okay, now I remember!
Lump found 11/08
DX: 2/09 @52 TNBC
L. Mast. 3/26/09, SN-, BRCA-,
4.5 cm (post surgical)T2NOMO
Chemo: 4/09-10/09 Taxol x 12,
A/C x 4, No rad.No recon. NED 1/17. New Primary right breast TN, 2/2018.
Back to Top
 Post Reply Post Reply
  Share Topic   

Forum Jump Forum Permissions View Drop Down

Forum Software by Web Wiz Forums® version 11.05
Copyright ©2001-2016 Web Wiz Ltd.