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ACT vs. TCa

Printed From: TNBC Foundation
Category: TNBC Forums
Forum Name: TNBC Talk
Forum Description: A place to chat
Printed Date: Mar 21 2019 at 2:57pm
Software Version: Web Wiz Forums 12.01 -

Topic: ACT vs. TCa
Posted By: lbpontel
Subject: ACT vs. TCa
Date Posted: Jan 03 2019 at 3:38pm
I had a Stage 1 TNBC (1.2cm); took three lumpectomies to get clear margins but got it all out. Now preparing for chemo and was prepared for a 16 week regimen of Adriamycin, Cyclophosphamide (Cytoxan), and Taxol (ACT). An expert second opinion was suggesting TCa regimen -- Taxotere and Carboplatin suggesting that the side effects were less. My current oncologist is saying there is not enough data to confirm TCa is as effective as ACT. Any experience out there? Thanks.

Posted By: Meadow
Date Posted: Jan 03 2019 at 5:43pm
I'm not surprised to hear that TCa is likely to have less side effects. But would it be as effective as ACT? That would be the key question for me and I don't see it answered in your post. I was treated 9 years ago, when Carboplatin was not considered for chemo regimens following first diagnosis of Stage I. My oncologist gave me two options: ACT, or TC (taxotere + Cytoxan). There were stats showing ACT was slightly more effective (a couple percentage points) but also tended to have harsher side effects, including a very small chance of serious heart damage. I chose the ACT. I wanted to reduce my risk of recurrence as much as possible and was willing to take on the added risks for those extra percentage points. Side effects from the ACT were not easy, but considerably easier than I anticipated. Taxotere was not hard - I just had fatigue and some temporary neuropathy.

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