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Xeloda & 5-fluorouracil

Printed From: TNBC Foundation
Category: TNBC Forums
Forum Name: Let's Talk About Chemotherapy
Forum Description: A place to discuss Chemotherapy
URL: http://forum.tnbcfoundation.org/forum_posts.asp?TID=13110
Printed Date: Mar 28 2024 at 8:16am
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Topic: Xeloda & 5-fluorouracil
Posted By: rstar
Subject: Xeloda & 5-fluorouracil
Date Posted: Apr 17 2017 at 5:02am
Hi there,

My mom was treated with the standard neoadjuvant AC+T & also received 5-fu as part of her CMF adjuvant regimen. 6 months later she recurred with lung mets and after a whole year on a parp trial, the oncologist put her on xeloda. Here is my question.. Isn't xeloda and 5-fu the same? Doesn't she basically put her back on a drug that she already progressed on since it didn't prevent the mets?



Replies:
Posted By: gordon15
Date Posted: Apr 17 2017 at 4:31pm
I don't know your answer but I would ask the same question directly to her oncologist, email it to him/her in writing if needbe, and save a copy.


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wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017


Posted By: 123Donna
Date Posted: Apr 18 2017 at 11:02pm
rstar,

Good question and probably one to ask your mother's oncologist.  I found this description of the two:
"Capecitabine is a rationally designed 5-FU pro-drug developed to mimic the continuous infusion of 5-FU while avoiding complications and inconvenience of intravenous administration. Capecitabine is absorbed intact from the gastrointestinal tract, converted enzymatically to active 5-FU, and released directly into the tumor. "
http://link.springer.com/article/10.1007%2Fs12156-011-0074-3" rel="nofollow - http://link.springer.com/article/10.1007%2Fs12156-011-0074-3


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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15



Posted By: rstar
Date Posted: Apr 19 2017 at 3:16pm
I did ask the oncologist and she said that while the treatment was given to her earlier in a different setting before she had mets, it's still remains an option to use it in the metastatic setting. Maybe because tumors go thru a genetic transformation sometimes? Not sure, but honestly I'm still not convinced.. 


Posted By: 123Donna
Date Posted: Apr 19 2017 at 6:43pm
rstar,

Sometimes Xeloda is often used in the first line of mets treatment to the lungs as it's easily tolerable and in pill form.

Have you considered getting a second opinion for treatment options?




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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15



Posted By: rstar
Date Posted: Apr 23 2017 at 2:28pm
Thx Donna,

Yea, I'm working on a second opinion.



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