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Positive nodes after neoadjuvent chemo

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Jdm4 View Drop Down
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    Posted: Nov 01 2018 at 11:03pm
I was diagnosed on April 24, 2018 with Tnbc in the right breast with multiple tumors and 7 lymph nodes. Went thru neoadjuvent chemo 2 months of AC and 12 weeks of Taxol. Just had bilateral mastectomy and had .9cm left in the breast and 9 positive lymph nodes. Original tumors combined were over 7cm. Chemo was effective in the breast but didn’t do much in the lymph nodes. I had asked my Onc and surgeon why the lymph nodes did not respond so well and was not given an answer other than we don’t know. They just tell me it is an unusual case. Will be doing radiation for 6 weeks once i am 4 weeks out from surgery then Zeloda for 6 months. Receptor status was rechecked in tumor and lymph nodes and all still Tnbc. Anyone else have similar issue with lymph nodes not responding so well? Feel like i am not getting answers and am scared and concerned about the treatments coming up. Going to get a second opinion to make sure the recommended treatment is my best option.
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rstar View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Nov 03 2018 at 4:42pm
Hi there

Unfortunately, there is no specific answer as to why one area responds better than others, but do ask your oncologist why Carboplatin wasn't added to your weekly taxol treatment cuz there is evidence that it improves responds in Triple Negative. Also, ask her to consider giving you 4 cycles of it before you start Xeloda.

Good luck and keep us posted.


Edited by rstar - Nov 04 2018 at 12:10pm
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Lisa s View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Lisa s Quote  Post ReplyReply Direct Link To This Post Posted: Nov 03 2018 at 7:23pm
Is carboplatin common? It was not even offered to me...does it depend on stage and brca status?
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Jdm4 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Jdm4 Quote  Post ReplyReply Direct Link To This Post Posted: Nov 03 2018 at 7:25pm
Thank you for your response. I am actually getting a second opinion on Friday and will ask his opinion. I am also going to ask my current oncologist about doing carboplatin in addition to the Xeloda. Appreciate it!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Nov 04 2018 at 7:39am
Hi Lisa

Carboplatin is not part of the standard protocol (yet), but oncologists tend to add it when a woman is at a higher risk of reccurance, regardless of brca status. Basically when there's node involvement or a big mass in the breast. Hope that helps

Edited by rstar - Nov 04 2018 at 12:11pm
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Jdm4 Quote  Post ReplyReply Direct Link To This Post Posted: Nov 04 2018 at 8:42am
Thank you for commenting on Lisa’s comment. Will be pushing for the Carbo. I did see there were some clinical trials with Carbo. Looking into them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Nov 04 2018 at 8:53am
You're very welcome.

My mom was in a similar situation (and a brca1 carrier), did not receive Carbo by her oncologista and eventually reccured..This is a frustrating situation and I feel obligated to try and help others if I can.

Edited by rstar - Nov 04 2018 at 12:16pm
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Kellyless Quote  Post ReplyReply Direct Link To This Post Posted: Nov 07 2018 at 1:31pm
I had a recurrence (very rare), did Carboplatin and Taxol. Got a complete response, all cancer gone or dead at mastectomy. It had been 2-ish cm before chemo. Most people do well on Carboplatin. I was sick as a dog, ended up hospitalized at one point. Eventually figured out what combination of drugs and stuff kept me going and got thru it. Totally worth it for the outcome!
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!
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