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PD-L1 Therapy for Metastatic Triple Negative

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pj123 View Drop Down
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    Posted: Apr 29 2017 at 1:39pm
Follow up on http://forum.tnbcfoundation.org/topic13067_post130990.html

Recently the doctor suggested to get a test for PD-L1 expression for my aunt. I wanted to ask if anyone has undergone this therapy for Metastatic Triple negative breast cancer. If yes it would be valuable if they can share their experience. 

Another question was there are many different tests of PD-L1 for various cancer, I think for breast cancer "PD-L1, IHC with Interpretation" (http://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=94007) is the one that should be done, am I right ? Also, if test shows that the therapy is applicable then the doctor suggested that "Avelumab" drug will be used which I guess the doctor will tell us how and where to get it from.

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gordon15 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 30 2017 at 10:28am
Has she had any molecular genetic testing of the tissue? My wife's doctor sent out to FoundationOne lab, they found "EGFR" (F795C) gene mutation and recommended "Lapatinib" (FDA approved in her cancer type) should she have recurrence. They even listed the approved therapy drugs "in other cancer types" Of course, we have no idea what will work in the future, but this is latest research (Moores Cancer Cntr)

Also sent to Carris.,
 sorry... I don't see anything about PD-LI in her results. She is 66 yrs old, your aunt is younger, perhaps inquire?
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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pj123 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote pj123 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 30 2017 at 11:06am
Thank you for the reply. 

No molecular genetic testing has been done so far in her case. Yes, she is younger (52 years old). When you said "perhaps inquire" did you mean inquire with the doctor to get her genetic testing done or something else ?

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gordon15 View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 30 2017 at 11:16am
yes, inquire with the doctor .
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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Post Options Post Options   Thanks (1) Thanks(1)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 01 2017 at 8:09am
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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pj123 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote pj123 Quote  Post ReplyReply Direct Link To This Post Posted: May 01 2017 at 9:37am
Thank you for all the information. It is certainly helpful.
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