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new TX plan approved by FDA for TNBC

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    Posted: Mar 09 2019 at 9:05am
 Dear

The FDA has approved the frontline combination of atezolizumab plus nab-paclitaxel for patients with unresectable locally advanced or metastatic PD-L1–positive triple-negative breast cancer.


Dear Beloved TNBC family, I rarely post but have continued to help folks on this forum. Someone may have posted this. My apologies if that is the case. I am a patient advocate working as a volunteer and I am not a medical professional so I am not recommending that anyone here with "unresectable locally advanced or metastatic PD-L1 positive TNBC" try this treatment but certainly I think it warrants a conversation with your oncologist. From past experience sometimes oncologists are not aware. 

with my best wishes and love to all here,
Steve

p.s. I don't know if this link can be downloaded. Had trouble doing it.


https://www.onclive.com/web-exclusives/fda-approves-atezolizumab-combo-for-frontline-tnbc?eKey=c3RlcGhlbms4OEBnbWFpbC5jb20=&utm_medium=email&utm_campaign=ONC%20Breaking%20News%203-8-19&utm_content=ONC%20Breaking%20News%203-8-19+CID_06c314ece06224f53185a0230806de5e&utm_source=CM%20ONCLIVE&utm_term=READ%20MORE

Donna, someone, maybe you could help please so that this is easily downloaded? Thanks.


I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Mar 10 2019 at 7:26pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote SagePatientAdvocates Quote  Post ReplyReply Direct Link To This Post Posted: Mar 10 2019 at 7:49pm
Thanks, Donna..
I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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Post Options Post Options   Thanks (1) Thanks(1)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Mar 11 2019 at 7:56pm

FDA approves first immunotherapy regimen for breast cancer


The US Food and Drug Administration has granted its first approval to an immunotherapy regimen for breast cancer, the agency announced Friday.
The treatment received accelerated approval for triple-negative breast cancer that is locally advanced or metastatic, that cannot be surgically removed and whose cells include a protein called PD-L1. It comprises a combination of immunotherapy and chemotherapy: Tecentriq and Abraxane, respectively.

The FDA's decision comes after an October study published in the New England Journal of Medicine found that the therapy extended progression-free survival -- the amount of time in which a patient's cancer does not worsen. In the PD-L1 subgroup, the median progression-free survival for those receiving the combination treatment was 7.4 months, versus 4.8 months for those getting the chemotherapy with placebo, according to the FDA's announcement. The trial was funded by Genentech Inc., the maker of Tecentriq.

"This is the first time immunotherapy has worked in such a difficult to treat cancer, and is a huge step forward for these breast cancer patients," lead study author Dr. Peter Schmid of Queen Mary University of London said in an October statement.

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Squirrel59 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 17 2019 at 12:35pm
Hi,
I am new to the forum.
My sister has just started the Tecentriq for metastatic tnbc, had her 2nd dose last Tuesday.
Fingers crossed....
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Post Options Post Options   Thanks (1) Thanks(1)   Quote SagePatientAdvocates Quote  Post ReplyReply Direct Link To This Post Posted: Mar 17 2019 at 4:25pm
Hi Squirrel,

Welcome to a caring home. 

I am sure that our wonderful TNBC family shares my good wishes for your sister. 

warmly,

Steve
I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 17 2019 at 8:23pm
Steve, I want to take this opportunity to thank you and introduce you to all members, for Steve offered to call me locally here in San Diego at the depths of my wife's diagnosis and despair, offering to provide referrals to University/Cancer Centers for my wife. It was Steve's recommendations over the phone that prompted me to question my wife's oncologist at Scripps La Jolla about further genetic/molecular therapies. Because of Steve's insight, my wife was referred to Dr. Kurzrock at UCSD/Moores after exhausting the regular chemo (Taxol) regimes, as she had chemo containing Taxol in 2008, then again in 2016 when Steve and I talked...so now Dr. Kurzrock and staff are monitoring w/ PET scans every 6 months and have done genetic analysis and they are amazing scientists... so, again, I want to take this time to thank Steve for his generous advice.

Edited by gordon15 - Mar 18 2019 at 1:14am
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
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Post Options Post Options   Thanks (0) Thanks(0)   Quote SagePatientAdvocates Quote  Post ReplyReply Direct Link To This Post Posted: Mar 17 2019 at 10:55pm
Dear Gordon,

Thank you so much for your lovely words. Means more to me than you can imagine.

I have helped several hundred women from this marvelous TNBC family of ours, for almost ten years, but I always keep everything confidential, and shall; so the vast majority, here, are not aware. And I have been so busy with helping people with other illnesses (mainly other cancers in addition to breast), that I rarely post; but my heart remains with all of you and your families. 

Gordon, it is so heartening to know your bride is doing well. She and everyone here have been, are, and will always be in my prayers.

I feel honored, privileged and blessed to be a patient advocate. 

Thank you, again, for your kind thoughts.

with my love to all here,

Steve






Edited by SagePatientAdvocates - Mar 17 2019 at 10:57pm
I am a BRCA1+ grandson, son and father of women affected by breast/oc-my daughter inherited mutation from me, and at 36, was dx 2004 TNBC I am a volunteer patient advocate with SAGE Patient Advocates
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