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New article - please explain

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    Posted: Jul 15 2017 at 9:26am
http://www.cancertherapyadvisor.com/breast-cancer/breast-cancer-tnbc-brca-status-carboplatin-treatment-risk/article/675223/


The article states that Carboplation is more effective in non brca mutation carriers. I thought it was the exact opposite..
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Jul 15 2017 at 11:08am
It looks to me like there is a benefit using the carboplatin with BRCA positive, but not as much benefit as those who don't aren't BRCA 1/2 positive. I may be reading this wrong? In the world of research much is developing right before our eyes so glad you brought this to the forum.

Here's an article that is 3 years old
http://www.ascopost.com/issues/november-1-2014/for-triple-negative-breast-cancer-adding-carboplatin-to-anthracyclinetaxane-produces-benefit-but-how-much/
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Jul 15 2017 at 11:37am
Yea sure, mo problem. Btw..I thought I was reading this wrong too lol but then your article says something different..looks like there's benefit to both I guess.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jul 15 2017 at 1:16pm
We had a thread several years ago discussing this topic.  Lots of good articles and information in it - please read through it.  I also commented how I believe I benefited from a platinum treatment even though I'm BRCA negative.



DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Jul 15 2017 at 2:20pm
I'm aware of the benefit with brca but this article states something different. That's why I posted it
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jul 15 2017 at 3:05pm
Yes there may be some benefit for patients that are not BRCA positive.  In my example, I am BRCA negative, but benefited from Carboplatin when I had a recurrence.  I achieved NED after 2 cycles.  My onc believed my tumor was basal type.  I think the platinum chemos may be effective for nonBRCA patients too, maybe all or just a subset of those patients.

The following video talks about chemo in the metastatic environment.  The first part discusses TNBC patients with highly basal like tumors and subset that responded to a platinum chemo (cisplatin and some carboplatin).

http://www.youtube.com/watch?v=ccjj6LuI0Hc





Edited by 123Donna - Jul 15 2017 at 3:10pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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