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Lifestyle changes

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Post Options Post Options   Thanks (0) Thanks(0)   Quote New insight Quote  Post ReplyReply Direct Link To This Post Posted: May 27 2014 at 9:23am
Because of quitting red meat, dairy product and sugar, I actually lost weight after the treatment.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 28 2014 at 8:39am
Lifestyle changes improve biomarkers associated with breast cancer recurrence and mortality

A pair of Yale Cancer Center interventional studies involvingbreast cancer survivors found that lifestyle changes in the form of healthy eating and regular exercise can decrease biomarkers related to breast cancer recurrence and mortality. The abstracts are scheduled to be presented at the 2014 annual meeting of the American Society of Clinical Oncology in Chicago May 30-June 3rd.

"The findings of both studies support a growing body of research that suggests lifestyle interventions lower biomarkers associated with breast cancer recurrence and mortality, and improve quality of life," said Melinda Irwin, PhD, co-program leader of the Cancer Prevention and Control Research Program at Yale Cancer Center, associate professor of Epidemiology at Yale School of Public Health, and principal investigator on both studies.

The abstracts are below.

Effect of weight loss intervention on inflammatory and metabolic markers in breast cancer survivors. The lifestyle, exercise, and nutrition (LEAN) study. (#1505)

In this study, obese or overweight women were randomized into two groups - those who received weight loss and exercise counseling - and a usual care group that received a brochure about lifestyle changes. After six months, women in the weight loss counseling group experienced an approximate 30% decrease in C-reactive protein (CRP) levels compared with a minimal decrease in women randomized to the usual care group. CRP is a marker of chronic inflammation and higher CRP levels have been associated with a higher risk of breast cancer mortality. A dose-response effect was found in women randomized to weight loss counseling in that women who lost at least 5% body weight experienced an approximate 22% decrease in insulin, 38% decrease in leptin, and 55% decrease in CRP, compared to significantly less biomarker improvement in women randomized to weight loss who lost less than 5% body weight.

http://www.medicalnewstoday.com/releases/277290.php?tw

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Jun 12 2014 at 12:42pm
For women with positive IGF1 receptor, limiting carbohydrates could reduce breast cancer recurrence

Dartmouth researchers have found that reducingcarbohydrate intake could reduce the risk of breast cancerrecurrence among women whose tumor tissue is positive for the IGF-1 receptor. The study, "Risk of Breast Cancer Recurrence Associated with Carbohydrate Intake and Tissue Expression of IGFI Receptor," will appear in the July issue ofCancer Epidemiology Biomarkers & Prevention.

"There is a growing body of research demonstrating associations between obesitydiabetes, and cancer risk," said lead author Jennifer A. Emond, an instructor in the Department of Community and Family Medicine at the Geisel School of Medicine at Dartmouth College. "There are similarities between the biological pathways that underlie all of these conditions, and there is some evidence to suggest that over-activation of the insulin/insulin-like growth factor axis, which increases the availability of IGF1 in the blood, may relate to a poor prognosis among breast cancer survivors."

Receptors for IGF1 have been found in breast tumor tissue, and expression of those receptors may contribute to treatment resistance among breast cancer survivors. Since diet can influence insulin activation, the researchers wondered whether diet could impact breast cancer prognosis based on expression of the IGF1 receptor in the primary breast tumor tissue.

Using an unusual approach, this study assessed the combined association of two factors implicated in tumor growth - carbohydrate intake and IGF1 receptor status - to test whether activating the insulin/insulin-like growth-factor axis can impact breast cancer. Since carbohydrates stimulate the biological pathway that can increase concentrations of IGF1, the researchers focused on carbohydrate intake. The women they studied were part of a larger intervention trial called the Women's Healthy Eating and Living (WHEL) study conducted between 2001 and 2007.

"We found an association between increased breast cancer recurrence in women with a primary breast cancer tumor that was positive for the IGF1 receptor, which is consistent with other studies," said Emond. "We further found that a decreased carbohydrate intake was associated with decreased breast cancer recurrence for these women."

This is the first study to suggest that it might be possible to personalize recommended diets for breast cancer survivors based on the molecular characteristics of their primary tumor. Further research is needed to confirm these findings, and Emond notes that breast cancer survivors should not be concerned about dramatically lowering their carbohydrate intake based on this study.

"There are still many unanswered questions regarding this study, including what type of carbohydrate-containing foods may be the most important foods that breast cancer survivors should limit," she said. "Breast cancer survivors should continue to follow a plant-based dietary pattern as suggested by the American Association for Cancer Research and the American Cancer Association, which means eating lots of fiber rich vegetables, legumes, and fruits; consuming whole grains and also limiting refined grains, starchy vegetables, and added sugar."

http://www.medicalnewstoday.com/releases/278084.php?tw

DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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