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bjoangtx View Drop Down
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    Posted: Feb 09 2011 at 6:10pm
Recently I've read a number of studies that discuss Ki-67 as an independent variable with prognosis and direction of tx. I don't see many people that include that information in their signature line. Donna, I know that you do.
 
Mine was pretty high 85%. I was just curious if anyone else was willing to share that info.
 
Thanks
St 2 Gr 3 2/5 nodes dx 8/9 age 56 Neoadj ACT @ x 6 @3wks bi mst. 12/09 Infect expander 12/31 remvd, replcd 1/27. 28 rads 4/10 Brkn rib 5/10 PET   6/10 NED Recon 9/17 & 12/10 Ki67 85% basal
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Genie Quote  Post ReplyReply Direct Link To This Post Posted: Feb 09 2011 at 11:34pm
bjoangtx,
As you can see from my signature line, my KI-67 at the time of biopsy was 86% and 3 weeks later the results from the bi-lateral mastectomy showed a KI-67 of 99%. It will be 3 years in March since my diagnosis and so far I show NED (no evidence of disease). I feel very blessed!
DX 3/10/08 at age 67, IDC. Stage 1, Grade 3, 1.5 cm.
KI-67 99% at MX . Bilateral mastectomy 4/1/08 Node-, BRCA 1/2-,BARD1+, TX:Cytoxan/Taxotere x4,3 in family with TNBC
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Post Options Post Options   Thanks (0) Thanks(0)   Quote bjoangtx Quote  Post ReplyReply Direct Link To This Post Posted: Feb 10 2011 at 12:34am

I had neoadjuvant TAC. My Ki67 stayed the same both at biopsy and following chemo. Did hey test yours after chemo?

St 2 Gr 3 2/5 nodes dx 8/9 age 56 Neoadj ACT @ x 6 @3wks bi mst. 12/09 Infect expander 12/31 remvd, replcd 1/27. 28 rads 4/10 Brkn rib 5/10 PET   6/10 NED Recon 9/17 & 12/10 Ki67 85% basal
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 10 2011 at 7:56am
bjoangtx,

My KI-67 was on my biopsy report before surgery.  I had adjuvant chemo after my surgery.

Donna


Edited by 123Donna - Feb 10 2011 at 4:21pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote outnumbered Quote  Post ReplyReply Direct Link To This Post Posted: Feb 10 2011 at 8:24am
My path report showed  >20%  then in the body of the report it said "Since more than 20% of tumor cells are actively cycling (in the G1, S, G2 and M phases of the cell cycle), this tumor is considered to have a HIGH PROLIFERATION RATE."
 
Glad they were so specific Disapprove
 


Edited by outnumbered - Feb 10 2011 at 8:40am
~Sara

DX @ age 40 6/24/08 Stage 1 Grade 3 BRCA1+ 187delAG

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Post Options Post Options   Thanks (0) Thanks(0)   Quote TracyAMac Quote  Post ReplyReply Direct Link To This Post Posted: Feb 10 2011 at 9:01am
Laides,I am going to get my path report out and look for this . What does this number mean? Is higher good or not? Thanks

Tracy in Toronto
TN&non-TN tumors April/10 Gr3&2;1 metaplastic
Rmast.1/9 nodes w/isolated t.cells
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Bone cancer 1980 age17;surgery&chemo AC+Methotrexate
BRCA-ve
On hormone therapy & Metformin Trial
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 10 2011 at 9:04am
Tracy,

I believe the higher the number the faster the cells are dividing, ie, Grade 3.   For what it's worth, mine was 48% and I had a recurrence.  I've seen other women with KI-67 in the 90's that are NED many years later.

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote bjoangtx Quote  Post ReplyReply Direct Link To This Post Posted: Feb 10 2011 at 3:56pm

I'm not very good at posting links or even cut n paste for that matter but here's the abstract to one of the studies I've come across recently.

Source: Eur J Surg Oncol  |  Posted 9 weeks ago

Prognostic significance of Ki67 index after neoadjuvant chemotherapy in breast cancer; Tanei T, Shimomura A, Shimazu K, Nakayama T, Kim SJ, Iwamoto T, Tamaki Y, Noguchi S; European Journal of Surgical Oncology (EJSO) (Nov 2010)

PURPOSE: Recently, Ki67 index (cell proliferation marker) has been attracting a considerable attention as a prognostic factor in breast cancer but the prognostic significance of Ki67 after neoadjuvant chemotherapy (NAC) has rarely been examined. EXPERIMENTAL DESIGN: Primary breast cancer patients (n = 102) treated with NAC (sequential paclitaxel 12 cycles (q1w) and 5-FU/epirubicin/cyclophosphamide 4 cycles (q3w)) were recruited in the study. Ki67, estrogen receptor (ER) and progesterone receptor (PR) and breast cancer resistant protein (BCRP) and P-glycoprotein were determined by immunohistochemistry and HER2 was determined by FISH in tumor tissues obtained before and after NAC, and their association with patient prognosis (relapse-free survival) was examined. RESULTS: Of the 102 patients, pCR was achieved in 30 (29.4%). In the 72 non-pCR patients, Ki67 index significantly (P < 0.001) decreased after NAC. Ki67 index after NAC, but not Ki67 index before NAC, was significantly associated with a patient prognosis (P = 0.022). Multivariate analysis has shown that Ki67 index after NAC is a marginally significant (P = 0.05) prognostic factor and that other biomarkers including ER, PR, BCRP, and P-glycoprotein before and after NAC are not significant. CONCLUSIONS: Ki67 after NAC, but not before NAC, is prognostic in breast cancer patients, and might be clinically useful in the prognosis prediction of patients who do not achieve pCR after NAC. On the other hand, BCRP and P-glycoprotein before and after NAC are unlikely to be useful as prognostic factors in these patients.

 
St 2 Gr 3 2/5 nodes dx 8/9 age 56 Neoadj ACT @ x 6 @3wks bi mst. 12/09 Infect expander 12/31 remvd, replcd 1/27. 28 rads 4/10 Brkn rib 5/10 PET   6/10 NED Recon 9/17 & 12/10 Ki67 85% basal
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Post Options Post Options   Thanks (0) Thanks(0)   Quote TysMom Quote  Post ReplyReply Direct Link To This Post Posted: Feb 10 2011 at 4:43pm
I asked my onc about this about half way through my treatment.  His response was that he doesn't pay attention to it and doesn't base any of his treatments on it.
 
It made me feel better when he said that because mine was in the 90's.
44 at dx
TN IDC Gr3/St 3 1/17 nodes+
5cm tumor removed 3/12/10
Taxol weekly for 12 weeks FINISHED 7/21/10
9 Avastin FINISHED 9/1/10
DD A/C 4 tx-FINISHED 9/15/10
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MrsLyons Quote  Post ReplyReply Direct Link To This Post Posted: Feb 11 2011 at 11:06am
Mine was 91%...still in treatment.
DX IDC TNBC 11/10 age 32, Stage 3a, Grade 3, 3.5 cm, 1/9 nodes, Right, KI-67 91%, BRCA-1, ACx4 (12/13/10) followed by TXx12, BMX w/expanders (6/1/2011), Rads begin 7/11/11
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Post Options Post Options   Thanks (0) Thanks(0)   Quote LauraT Quote  Post ReplyReply Direct Link To This Post Posted: Feb 11 2011 at 4:56pm
I can't get my hands on the original biopsy report at the moment, but my recollection is that prior to chemo, it was around 90%.  After chemo at the time of surgery, it was 13% (the path report says "borderline").
DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva
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Post Options Post Options   Thanks (0) Thanks(0)   Quote lady4law Quote  Post ReplyReply Direct Link To This Post Posted: Feb 22 2011 at 12:40am
I don't recall the exact number, think it was 89, however I do recall my Oncologist (s) and surgeon mentioning they had not had another patient with numbers that high, encouraging right? 
IBC/TN 6/07 Lymph, Chemo, Mast w/rec, chemo, 2 infect surg, exchg (2x) redo rec (2x) 4 new tumors esophagus, colon, chest, mouth, (10/11- 5th SUV7)"Activity" in spine hip
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Post Options Post Options   Thanks (0) Thanks(0)   Quote bjoangtx Quote  Post ReplyReply Direct Link To This Post Posted: Feb 22 2011 at 12:44am
Actually from what I've read if there is a drop in the Ki-67 in response to treatment that's a good sign. Mine didn't change. It was 85% at biopsy and 85% after chemo. The fact that yours went down to 13% is a positive sign.
St 2 Gr 3 2/5 nodes dx 8/9 age 56 Neoadj ACT @ x 6 @3wks bi mst. 12/09 Infect expander 12/31 remvd, replcd 1/27. 28 rads 4/10 Brkn rib 5/10 PET   6/10 NED Recon 9/17 & 12/10 Ki67 85% basal
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Post Options Post Options   Thanks (0) Thanks(0)   Quote LauraT Quote  Post ReplyReply Direct Link To This Post Posted: Feb 22 2011 at 6:24am

That is encouraging, especially in light of the fact that the chemo did not really shrink my tumor and that put me in the "considerable residual disease" category with higher risk for recurrence.

DX 10/09 @44, Stage I IDC tnbc, DCIS other side, Neoadjuvant TCx4, Bilateral Mastectomy w/Recon 1/10, 1.2cm 0/7 Nodes, 5/11 Mets to Lungs/Lymph Nodes, Avastin/Taxol, 10/11 Bone Mets, Xgeva
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Post Options Post Options   Thanks (0) Thanks(0)   Quote lady4law Quote  Post ReplyReply Direct Link To This Post Posted: Feb 22 2011 at 3:38pm
I was told this test could only be done when the original tumor was removed, biopsied or surgery. As it tells the speed the tumor is dividing. My Onc told me he cannot run the test after the tumor has been removed. Of course, new tumors or mets would allow for the test to be redone. Not the same as the cancer marker blood tests
IBC/TN 6/07 Lymph, Chemo, Mast w/rec, chemo, 2 infect surg, exchg (2x) redo rec (2x) 4 new tumors esophagus, colon, chest, mouth, (10/11- 5th SUV7)"Activity" in spine hip
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Post Options Post Options   Thanks (0) Thanks(0)   Quote trip2 Quote  Post ReplyReply Direct Link To This Post Posted: Mar 03 2011 at 3:34pm
Stage 2 2003
Stage 1 2007
BRCA 1+
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Post Options Post Options   Thanks (0) Thanks(0)   Quote outnumbered Quote  Post ReplyReply Direct Link To This Post Posted: Mar 03 2011 at 3:38pm
Thanks Pam, very interesting. 
~Sara

DX @ age 40 6/24/08 Stage 1 Grade 3 BRCA1+ 187delAG

BMX (nipple-areola-sparing) 8/5/08

Redo BMX (remove nipple and areola) w/ Lat Flap 7/6/09

BSO 9/3/09

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Post Options Post Options   Thanks (0) Thanks(0)   Quote ivygreen Quote  Post ReplyReply Direct Link To This Post Posted: Apr 06 2011 at 7:15pm
I  am awaiting for the results of mine. I would be happy to post.
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