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Lillie
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Joined: Jul 10 2009
Location: Eastern NC
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Posted: Jul 15 2014 at 6:02pm |
Hi Sisters, Just wanted to share that I got the results of my labs yesterday when I had my yearly physical by my GP. I requested a Vitamin D check this year. The reading was 56. I have been taking 4000 units daily for most of the past year. 2 years ago the reading was in the mid 60's at which time I was taking 5000 units daily. I'm thinking I will up my dosage to 5,000 again. 56 is good, but I think I'd rather be in the mid 60's. My doctor gave me an overall grade of 'A'. I will be getting a mammogram soon and then my 1 year check with my oncologist in August. For an 'ole lady' I'm doing OK. God Bless, Lillie
Edited by Lillie - Jul 15 2014 at 6:03pm
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Dx 6/06 age 65,IDC-TNBC Stage IIb,Gr3,2cm,BRCA- 6/06 L/Mast/w/SNB,1of3 Nodes+ 6/06 Axl. 9 nodes- 8/8 thru 11/15 Chemo (Clin-Trial) DD A/Cx4 -- DD taxol+gemzar x4 No Rads. No RECON - 11/2018-12 yrs NED
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MLindaG
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Joined: Feb 16 2013
Location: Pittsburgh PA
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Posted: Jul 15 2014 at 6:21pm |
Oh Lillie! So happy for the good news!! Sounds like you are doing great!! I'm in the middle of all the MD appointments myself.....so far so good!! I really can't believe it's been 2 years since this all started! I can't wait until I'm 8 years out!! :)
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Dx TNBC 6/12; age 59; Stage 3, Grade 3; 3.5 cm, 3/10 nodes + chest wall nodes; A/C x4, T x 12 completed 12/12 with PCR, 2/13/13 lump; IMRT Rads x 33 completed 5/22/13 BRCA 1 negative.
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123Donna
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Location: St. Louis, MO
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Posted: Jul 15 2014 at 7:15pm |
Lillie,
You are doing more than just OK my friend! Glad your levels are staying in a good range.
Donna
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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mainsailset
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Location: Washington State
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Posted: Jul 15 2014 at 9:10pm |
Oh Lillie that is such grand news! I just saw a new report out that pointed towards a good level of D fighting cancer, not news to us but this was coming from my NIH email list so maybe we've finally convinced the unconvinceable! (well at least they admit that it m a y b e so, sigh.)
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dx 7/08 TN 14x6.5x5.5 cm tumor
3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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Jojocat
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Joined: Jan 11 2014
Location: New York
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Points: 108
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Posted: Jul 15 2014 at 10:03pm |
Vitamin D =simple+effective +hope
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DX 10/24/2013 Between stage 2b and 3a. 2 big nods 1.8cm a d 1.4 cm. tumor 4.5 cm. 35 years old. 11/15/2013. AC/T
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sue
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Joined: Aug 13 2010
Location: NJ
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Points: 650
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Posted: Jul 16 2014 at 4:32pm |
Dear Lillie,
So happy to hear the good news! Thank you for sharing with us.
Love and Peace, Sue
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Dx 7/10, age 53. TNBC left breast, stage I, grade 3, IDC 0.5 cm, DCI 2.5 cm, 0/8 lymph nodes neg. BRCA-. T/C x4 finished 2/09/11, rads x34 finished 4/21/11.
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JackiWalkr
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Joined: Jun 25 2014
Location: California
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Posted: Jul 16 2014 at 4:49pm |
Wow 56 I was only 37 and no one told me to up my D3 I just started taking 1000 to bump it. Sounds like I need a lot more. Thanks for giving us all hope. Jackie
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DX IDC TNBC 3/31/14 Age 46 Stage 2a, Grade 3, 2.1cm, 0 nodes, (4)Carbo(5)Taxol. AC DD 4 of 4. Lumpectomy 10/30/2014 NED. 33 Rads 2/12/15. BRCA 1/2 normal=negative
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123Donna
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Posted: Jul 16 2014 at 8:26pm |
For JackiWalkr-
123Donna wrote:
,
Here's some information from the Vit D Council:
These are the ranges that different organizations in the United States use to say whether you’re severely lacking in vitamin D (deficient), mildly lacking in vitamin D (insufficient) or whether you’re getting enough vitamin D (sufficient): Vitamin D 25(OH)D range guidelines from various organizations: | Vitamin D Council | Endocrine Society | Food and Nutrition Board | Testing Laboratories | Deficient | 0-30 ng/ml | 0-20 ng/ml | 0-11 ng/ml | 0-31 ng/ml | Insufficient | 31-39 ng/ml | 21-29 ng/ml | 12-20 ng/ml | | Sufficient | 40-80 ng/ml | 30-100 ng/ml | >20 ng/ml | 32-100 ng/ml | Toxic | >150 ng/ml | | | |
The Vitamin D Council suggests that a level of 50 ng/ml is the ideal level to aim for. This is why the Council recommends that adults take 5,000 IU/day of vitamin D supplement in order to reach and stay at this level. http://www.vitamindcouncil.org/about-vitamin-d/testing-for-vitamin-d/
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Edited by 123Donna - Jul 16 2014 at 8:27pm
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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123Donna
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Posted: Jul 16 2014 at 9:57pm |
Vitamin D Research:
Edited by 123Donna - Jul 18 2014 at 11:59am
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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JackiWalkr
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Posted: Jul 16 2014 at 9:59pm |
Wow, great info everywhere I look. So thankful for everyone here. -Jackie
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DX IDC TNBC 3/31/14 Age 46 Stage 2a, Grade 3, 2.1cm, 0 nodes, (4)Carbo(5)Taxol. AC DD 4 of 4. Lumpectomy 10/30/2014 NED. 33 Rads 2/12/15. BRCA 1/2 normal=negative
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Lillie
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Posted: Jul 17 2014 at 10:25am |
When people ask why I take Vitamin D3.
I say, "my medicine bottle says, Vitamin D3 is essential for absorption of Calcium and necessary support for healthy bones, teeth and immune system. Vitamin D3 also supports breast and colon health."
I've had breast cancer and that is all the more reason I want to support my breast, and immune system health.
For me it was breast cancer that woke me from my blissful slumber of ignorance about vitamin D3.
I really love it when someone prompts a new member here to get their Vitamin D checked. We never know what a huge difference it can make in our continued survival.
God Bless, Lillie
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Dx 6/06 age 65,IDC-TNBC Stage IIb,Gr3,2cm,BRCA- 6/06 L/Mast/w/SNB,1of3 Nodes+ 6/06 Axl. 9 nodes- 8/8 thru 11/15 Chemo (Clin-Trial) DD A/Cx4 -- DD taxol+gemzar x4 No Rads. No RECON - 11/2018-12 yrs NED
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susanwe
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Posted: Aug 10 2014 at 1:00pm |
Wonderful study on how Vitamin D3 in your blood serum can stop TNBC cell growth. Published in the Journal of Cell Biology, January 21, 2013 lead researcher is Susan Gonzalo.
Newest research and subsequent recommendations re: blocking all types of breast cancer growth, is to keep your vitamin D3 blood serum level at 80 ng/ml.. from Dr Cedric Garland's work at Moores Cancer Center in San Diego. To stay up to date with all D3 and breast cancer recommendations go to www.grassrootshealth.net
To maximize whatever supplement dose you are now taking, take supplement with your largest meal of the day. Also get daily dose of THE SUN!! 10 minutes on each side of body... indoor or outdoor tanning will work... just DO NOT BURN!!! This applies to all black and dark skinned Hispanic women and to white women who are able to develop any kind of tan. See www.bustingbreastcancer.org
Nice to have such good D3 news when it comes to TNBC!!!
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Susan W-E
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Posted: Aug 26 2014 at 10:41pm |
The most knowledgeable person re: vitamin D3 and how it can protect a woman from a recurrence is Carole Baggerly, director of Grassroots Health .. she is also a breast cancer survivor. She will be speaking at the free on-line national cure to cancer summit next week, along with Kelly Turner, author of " Radical Remission" and Bill Henderson, author of "Cancer Free." I am new to the forum.. is there a way to let more interested members know about Carole's free on line talk next week... she is filled with information on every aspect of vitamin D3 and breast cancer prevention.
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Julz
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Posted: Aug 27 2014 at 8:03am |
Just stumbled upon this. My medical Onc. told me mine was fine at 34 & that I was to take 2000 a day. When they did this test I had already been taking 2,000 D3 a day for 2 months. But I have heard for years through reading & my local support group that they want it at 50. I want a new test again as my level went down to 31 the last time. The more I read the more I don't like at all! Vitamin D is my "Chemo" so to speak as my tumor was Micro invasive. I only had to have RADS. I am 2 years out since the end of my RADS. I had a finger ex-ray January & she asked if I had radiation treatments. She asked because I am already showing the effects/start of Osteopinia (sp). This was on the left hand, surgery side.
On another footnote about Vitamin D. My youngest (oldest too) Son/s has Crohn's disease. He was DX at age 11 & is now 15. About from the beginning of his DX (diagnosis) he started getting Strep Throat many times throughout the year. He has had his tonsils out & his Pediatrician said he had been reading research on D levels & infection in people with disease's. That they should make sure their levels are high enough because they are more prone to getting infections. I am very happy to say that his last levels went up from 37 to 58 & he has not had strep throat since! Think about it our Diets & the medicines we take today effect the way our body absorbs nutrients! Anyway I think it's something definitely to think about & to discuss with our Dr's!
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Partial Mastectomy & CNB 5/22/2012, DX 5/30/2012 DCISMI, 2.8cm, Tumor stage T1, Grade 2-3/3, 0/2 nodes, ER-/PR-/HER2? not enough invasive tissue to test. 33 rounds whole breast radiation.
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123Donna
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Posted: Sep 09 2014 at 8:06am |
Does the association between vitamin D status and breast cancer vary between ethnicities?
After running their statistical analyses, the research team found the following results: - Mean total vitamin D level was highest among whites (36.15 ng/ml) and lowest among African Americans (26.05 ng/ml). Native Hawaiians, Japanese, and Latinos had average total vitamin D levels of 33 ng/ml, 32.65 ng/ml, and 27.4 ng/ml, respectively.
- White participants in group with breast cancer with a total level below 20 ng/ml had a 7.5 times increased risk of breast cancer compared to white participants with a total level above 20 ng/ml.
- Both higher total vitamin D and vitamin D3 levels were associated with a decreased risk of breast cancer among white women.
- For participants in the other ethnic groups, the association of total vitamin D and vitamin D3 levels with breast cancer was insignificant.
The researchers summarized the results by saying, “In conclusion, plasma vitamin D was inversely associated with postmenopausal breast cancer risk among white women who reside in latitudes where levels of ultraviolet radiation are comparatively high. It is likely that a minimum threshold of vitamin D exposure from both sun and diet is required to achieve a reduction in breast cancer risk among postmenopausal white women.”
They also touched upon the subject of genetics, as genes may also explain the puzzling results. These results are very interesting and add a new layer of complexity to the vitamin D and breast cancer investigation. As the researchers mention, the fact that an association between vitamin D3 and total vitamin D levels was only seen in whites, who had the highest levels of any ethnicity, suggests that a threshold exists for a protective effect of vitamin D on breast cancer development. Furthermore, this threshold may be relatively high, as no group had an average vitamin D level below 27.4 ng/ml. In this study, it is hard to attribute the lack of association observed in the other ethnic groups to differences in skin type, latitudinal location, or vitamin D production. This study highlights the need for more research on the relationship between breast cancer, sun exposure, and vitamin D across different ethnic groups. Yet, it supports previous research suggesting a high vitamin D cutoff of 40 ng/ml needed for breast cancer protection. Source Kim, Y. et al. Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case-control study in the multiethnic cohort study. BMC Cancer, 2014. http://www.vitamindcouncil.org/blog/does-the-association-between-vitamin-d-status-and-breast-cancer-vary-between-ethnicities
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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123Donna
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Posted: Nov 12 2014 at 7:43pm |
Bumping for new members. We should all know our Vitamin D levels. Most of us had very low levels at diagnosis. This should be a number we all know, just like cholesterol and blood pressure. If you don't know your number, please ask your doctor for this test. It's a simple blood test.
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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lilyrose
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Posted: Nov 13 2014 at 3:42pm |
I wholeheartedly agree with you Donna! My PCP had me tested a few years ago before I was dx with BC. My level was 14. He put me on D3 immediately. 2000 IU daily. It took six months just to get above 20! He told me to go up to 4000IU. My latest number was 40 a few months ago. Was told to stop taking all antioxidants while doing rads. Just finished rads yesturday and am back on 4000 IU daily. Saw my PCP today and he said to go for it. He also ordered a new test to check my levels again. He said he would like to see me get above 50. I'm so grateful he is taking this seriously.
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DX 2/14, age 60, IDC TNBC BRCA- Stage 1,Grade 3, lumpectomy 3/14, 2cm, 0/4 nodes, clear margins
4/14, A/C DD 4rounds 6/14 Taxol weekly x 12 9/25 Rads 26 + 8 boosts
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123Donna
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Posted: Dec 16 2014 at 8:33am |
Vitamin D deficiency may drastically increase risk of clostridium difficile infection
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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123Donna
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Posted: Jan 30 2015 at 5:54pm |
Low Vitamin D Linked to Aggressive Breast Cancerhttp://www.webmd.com/breast-cancer/news/20110429/low-vitamin-d-linked-to-aggressive-breast-cancer
Modeling vitamin D actions in triple negative/basal-like breast cancerAbstractBreast cancer is a heterogeneous disease with six molecularly defined subtypes, the most aggressive of which are triple negative breast cancers that lack expression of estrogen receptor (ER) and progesterone receptor (PR) and do not exhibit amplification of the growth factor receptor HER2. Triple negative breast cancers often exhibit basal-like gene signatures and are enriched for CD44+ cancer stem cells. In this report we have characterized the molecular actions of the VDR in a model of triple negative breast cancer. Estrogen independent, invasive mammary tumor cell lines established from wild-type (WT) and VDR knockout (VDRKO) mice were used to demonstrate that VDR is necessary for 1,25-dihydroxyvitamin D3(1,25D) mediated anti-cancer actions in vitro and to identify novel targets of this receptor. Western blotting confirmed differential VDR expression and demonstrated the lack of ER, PR and Her2 in these cell lines. Re-introduction of human VDR (hVDR) into VDRKO cells restored the anti-proliferative actions of 1,25D. Genomic profiling demonstrated that 1,25D failed to alter gene expression in KO240 cells whereas major changes were observed in WT145 cells and in KO clones stably expressing hVDR (KOhVDR cells). With a 2-fold cutoff, 117 transcripts in WT145 cells and 197 transcripts in the KOhVDR clones were significantly altered by 1,25D. Thirty-five genes were found to be commonly regulated by 1,25D in all VDR-positive cell lines. Of these, we identified a cohort of four genes (Plau, Hbegf, Postn, Has2) that are known to drive breast cancer invasion and metastasis whose expression was markedly down regulated by 1,25D. These data support a model whereby 1,25D coordinately suppresses multiple proteins that are required for survival of triple-negative/basal-like breast cancer cells. Since studies have demonstrated a high prevalence of vitamin D deficiency in women with basal-like breast cancer, correction of vitamin D deficiency in these women represents a reasonable, but as yet untested, strategy to delay recurrence and extend survival. http://www.sciencedirect.com/science/article/pii/S096007601300215X
Vitamin D Holds Promise in Battling a Deadly Breast Cancer, SLU Researchers Say
Here's some information from the Vit D Council:
These are the ranges that different organizations in the United States use to say whether you’re severely lacking in vitamin D (deficient), mildly lacking in vitamin D (insufficient) or whether you’re getting enough vitamin D (sufficient): Vitamin D 25(OH)D range guidelines from various organizations: | Vitamin D Council | Endocrine Society | Food and Nutrition Board | Testing Laboratories | Deficient | 0-30 ng/ml | 0-20 ng/ml | 0-11 ng/ml | 0-31 ng/ml | Insufficient | 31-39 ng/ml | 21-29 ng/ml | 12-20 ng/ml | | Sufficient | 40-80 ng/ml | 30-100 ng/ml | >20 ng/ml | 32-100 ng/ml | Toxic | >150 ng/ml | | | |
The Vitamin D Council suggests that a level of 50 ng/ml is the ideal level to aim for. This is why the Council recommends that adults take 5,000 IU/day of vitamin D supplement in order to reach and stay at this level. http://www.vitamindcouncil.org/about-vitamin-d/testing-for-vitamin-d/
Edited by 123Donna - Jan 30 2015 at 5:54pm
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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mainsailset
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Posted: Jan 30 2015 at 6:06pm |
May the researchers someday finally catch up to what we've noticed all along.
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dx 7/08 TN 14x6.5x5.5 cm tumor
3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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