I am taking zometa currently with my chemo, and have been since July. I get it once a month. I haven't had any problems with it, outside of the first treatment. That hit me like a truck--you know that awful feeling you get with the flu? It was like that but way worse. So on the 2nd dose, I asked them to increase my fluids, which as far as I know they did, and I haven't had that problem since. I was concerned about my teeth, but my onco said that since I have good dental hygiene, I will be ok. We'll see what my dentist says next month! :)
I also had a brain MRI (2 actually) before starting treatment. One was required for the study that I am on, but the first one, I think may have been just a check.