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123Donna
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Topic: New article - please explain Posted: Jul 15 2017 at 3:05pm |
Yes there may be some benefit for patients that are not BRCA positive. In my example, I am BRCA negative, but benefited from Carboplatin when I had a recurrence. I achieved NED after 2 cycles. My onc believed my tumor was basal type. I think the platinum chemos may be effective for nonBRCA patients too, maybe all or just a subset of those patients.
The following video talks about chemo in the metastatic environment. The first part discusses TNBC patients with highly basal like tumors and subset that responded to a platinum chemo (cisplatin and some carboplatin). http://www.youtube.com/watch?v=ccjj6LuI0Hc
Edited by 123Donna - Jul 15 2017 at 3:10pm
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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rstar
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Posted: Jul 15 2017 at 2:20pm |
I'm aware of the benefit with brca but this article states something different. That's why I posted it
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123Donna
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Posted: Jul 15 2017 at 1:16pm |
We had a thread several years ago discussing this topic. Lots of good articles and information in it - please read through it. I also commented how I believe I benefited from a platinum treatment even though I'm BRCA negative.
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
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rstar
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Posted: Jul 15 2017 at 11:37am |
Yea sure, mo problem. Btw..I thought I was reading this wrong too lol but then your article says something different..looks like there's benefit to both I guess.
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mainsailset
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Posted: Jul 15 2017 at 11:08am |
It looks to me like there is a benefit using the carboplatin with BRCA positive, but not as much benefit as those who don't aren't BRCA 1/2 positive. I may be reading this wrong? In the world of research much is developing right before our eyes so glad you brought this to the forum. Here's an article that is 3 years old http://www.ascopost.com/issues/november-1-2014/for-triple-negative-breast-cancer-adding-carboplatin-to-anthracyclinetaxane-produces-benefit-but-how-much/
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dx 7/08 TN 14x6.5x5.5 cm tumor
3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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rstar
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Posted: Jul 15 2017 at 9:26am |
http://www.cancertherapyadvisor.com/breast-cancer/breast-cancer-tnbc-brca-status-carboplatin-treatment-risk/article/675223/The article states that Carboplation is more effective in non brca mutation carriers. I thought it was the exact opposite..
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