Author |
Topic Search Topic Options
|
atlhoosier
Groupie
Joined: Feb 18 2014
Status: Offline
Points: 46
|
Post Options
Thanks(0)
Quote Reply
Topic: Reparixin + Taxol Study Posted: Jun 06 2017 at 1:18pm |
Hi everyone. I am newly diagnosed stage 4 and was wondering if anyone has participated in a trial that combines taxol with reparixin? It's fairly new, randomized and in phase 2. I was wondering how you are responding and any side effects. Thank you!
|
DX Jan 2014, 37yo TNBC, Stage 2A, 4 tumors, BMX Aug 2014, clear margins
2017 - Mets to lung (single nodule) & sacrum 1st line(current): clinical study w/ taxol & reparixin (may be placebo)
|
|
123Donna
Senior Member
Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 13509
|
Post Options
Thanks(1)
Quote Reply
Posted: Jun 07 2017 at 8:05am |
I'm sorry you are dealing with a recurrence. Where did it metastasize? I don't have any information on this study, but there was this release of the results of hte Phase 1B study.
These are from older threads:
Reparixin is a CXCR1/2 inhibitor with a low molecular weight that in experimental studies has been shown to be able to reduce cancer stem cells if administered alone or in association with chemotherapy with medicines of the taxane family. With reparixin, the aim is to inhibit the activity of the "driving force" of the inflammation in order to keep under control the development of breast cancer stem cells and, potentially, other neoplasia as well, in addition to altering the microenvironment that allows their development.
SAN ANTONIO, December 11, 2014 /PRNewswire/ -- Other immunotherapy approaches “Our immunotherapy studies have moved from just vaccines to include checkpoint inhibitors and other immunotherapy strategies,” Dr. Mittendorf said. “And as an institution, we have the opportunity to do more.” For example, Dr. Ibrahim is the principal investigator at MD Anderson for an ongoing multi-institutional trial of the oral immunostimulant indoximod with taxane-based chemotherapy for patients with HER2-negative metastatic breast cancer. Indoximod inhibits the indoleamine 2,3-dioxygenase pathway, which suppresses T cell activity. Also under investigation are agents that block the action of interleukin-8 (CXCL8), which has an immunomodulatory effect and is associated with breast cancer growth and metastasis. A trial of one such agent, reparixin, which binds to the CXCL8 receptor CXCR1, is underway at MD Anderson and other institutions. Preclinical studies of promising therapies also are underway. For example, Dr. Mittendorf said, Laurence Cooper, M.D., Ph.D., a professor in the Division of Pediatrics, is investigating the use of T cells modified with chimeric antigen receptors (see “Sleeping Beauty” Technique Modifies T Cells to Treat B Cell Malignancies, OncoLog, May 2014) against triple-negative breast cancer.
|
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
|
|
atlhoosier
Groupie
Joined: Feb 18 2014
Status: Offline
Points: 46
|
Post Options
Thanks(0)
Quote Reply
Posted: Jun 07 2017 at 10:49am |
Hi Donna, I have a single nodule on my right middle lung, and also sacrum. :(
|
DX Jan 2014, 37yo TNBC, Stage 2A, 4 tumors, BMX Aug 2014, clear margins
2017 - Mets to lung (single nodule) & sacrum 1st line(current): clinical study w/ taxol & reparixin (may be placebo)
|
|
123Donna
Senior Member
Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 13509
|
Post Options
Thanks(1)
Quote Reply
Posted: Jun 07 2017 at 7:47pm |
I hope you will hear from others that might be in this trial. If you enter the trial, please keep us posted on how you are doing. Wishing you the best and you get to NED!
Donna
|
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09) 11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15
|
|
gordon15
Senior Member
Joined: Jun 22 2015
Location: San Diego CA
Status: Offline
Points: 788
|
Post Options
Thanks(0)
Quote Reply
Posted: Jun 07 2017 at 9:01pm |
|
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16 PET scan stable 9-2016/ 1-2017
|
|
atlhoosier
Groupie
Joined: Feb 18 2014
Status: Offline
Points: 46
|
Post Options
Thanks(1)
Quote Reply
Posted: Sep 15 2017 at 10:39am |
Just wanted to post an update if anyone reads this. After the first cycle of 2 months, my results did show that the tumor has shrunk from 13 x 10 mm to 11 x 7 mm!
|
DX Jan 2014, 37yo TNBC, Stage 2A, 4 tumors, BMX Aug 2014, clear margins
2017 - Mets to lung (single nodule) & sacrum 1st line(current): clinical study w/ taxol & reparixin (may be placebo)
|
|
Kellyless
Senior Member
Joined: Jun 18 2009
Location: Dallas, Texas
Status: Offline
Points: 1154
|
Post Options
Thanks(1)
Quote Reply
Posted: Sep 16 2017 at 2:11pm |
Congratulations! How are you doing with the side effects?
|
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads 6/1/16 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!
|
|
gordon15
Senior Member
Joined: Jun 22 2015
Location: San Diego CA
Status: Offline
Points: 788
|
Post Options
Thanks(0)
Quote Reply
Posted: Sep 17 2017 at 7:54pm |
Thanks for the update!
|
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16 PET scan stable 9-2016/ 1-2017
|
|
atlhoosier
Groupie
Joined: Feb 18 2014
Status: Offline
Points: 46
|
Post Options
Thanks(0)
Quote Reply
Posted: Sep 17 2017 at 11:44pm |
I'm doing fine...maybe decent is a better word. I think most of my side effects sten from the taxol--just the usual stuff--hair loss, neuropathy (not too bad), weight gain. Sometimes I'm a little gassy right after I take the study drug, but that's it.
|
DX Jan 2014, 37yo TNBC, Stage 2A, 4 tumors, BMX Aug 2014, clear margins
2017 - Mets to lung (single nodule) & sacrum 1st line(current): clinical study w/ taxol & reparixin (may be placebo)
|
|