New Posts New Posts RSS Feed - Xeloda & 5-fluorouracil
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Xeloda & 5-fluorouracil

 Post Reply Post Reply
Author
rstar View Drop Down
Groupie
Groupie


Joined: Nov 26 2015
Status: Offline
Points: 41
Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Topic: Xeloda & 5-fluorouracil
    Posted: Apr 17 2017 at 5:02am
Hi there,

My mom was treated with the standard neoadjuvant AC+T & also received 5-fu as part of her CMF adjuvant regimen. 6 months later she recurred with lung mets and after a whole year on a parp trial, the oncologist put her on xeloda. Here is my question.. Isn't xeloda and 5-fu the same? Doesn't she basically put her back on a drug that she already progressed on since it didn't prevent the mets?


Edited by rstar - Apr 17 2017 at 5:16am
Back to Top
gordon15 View Drop Down
Senior Member
Senior Member


Joined: Jun 22 2015
Location: San Diego CA
Status: Offline
Points: 788
Post Options Post Options   Thanks (0) Thanks(0)   Quote gordon15 Quote  Post ReplyReply Direct Link To This Post Posted: Apr 17 2017 at 4:31pm
I don't know your answer but I would ask the same question directly to her oncologist, email it to him/her in writing if needbe, and save a copy.
wife: IDC/Lobular Stage2B 2008 lumpectomy/TAC+rads
TNBC Stage 3A/w/metaplastic/squamous Nov2015 Carboplatin-Gemzar chemo/masectomy Taxolchemo+rads 4-16
PET scan stable 9-2016/ 1-2017
Back to Top
123Donna View Drop Down
Senior Member
Senior Member
Avatar

Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 13509
Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 18 2017 at 11:02pm
rstar,

Good question and probably one to ask your mother's oncologist.  I found this description of the two:
"Capecitabine is a rationally designed 5-FU pro-drug developed to mimic the continuous infusion of 5-FU while avoiding complications and inconvenience of intravenous administration. Capecitabine is absorbed intact from the gastrointestinal tract, converted enzymatically to active 5-FU, and released directly into the tumor. "
http://link.springer.com/article/10.1007%2Fs12156-011-0074-3
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Back to Top
rstar View Drop Down
Groupie
Groupie


Joined: Nov 26 2015
Status: Offline
Points: 41
Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Apr 19 2017 at 3:16pm
I did ask the oncologist and she said that while the treatment was given to her earlier in a different setting before she had mets, it's still remains an option to use it in the metastatic setting. Maybe because tumors go thru a genetic transformation sometimes? Not sure, but honestly I'm still not convinced.. 

Edited by rstar - Apr 19 2017 at 3:22pm
Back to Top
123Donna View Drop Down
Senior Member
Senior Member
Avatar

Joined: Aug 24 2009
Location: St. Louis, MO
Status: Offline
Points: 13509
Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Apr 19 2017 at 6:43pm
rstar,

Sometimes Xeloda is often used in the first line of mets treatment to the lungs as it's easily tolerable and in pill form.

Have you considered getting a second opinion for treatment options?


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

Back to Top
rstar View Drop Down
Groupie
Groupie


Joined: Nov 26 2015
Status: Offline
Points: 41
Post Options Post Options   Thanks (0) Thanks(0)   Quote rstar Quote  Post ReplyReply Direct Link To This Post Posted: Apr 23 2017 at 2:28pm
Thx Donna,

Yea, I'm working on a second opinion.
Back to Top
 Post Reply Post Reply
  Share Topic   

Forum Jump Forum Permissions View Drop Down

Forum Software by Web Wiz Forums® version 12.01
Copyright ©2001-2018 Web Wiz Ltd.