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"About half the women were followed for less than 3 years and the other half of the women were followed for more than 3 years. The researchers recorded how long the women lived without a recurrence of invasive breast cancer, called invasive disease-free survival.
During follow-up, more women treated with the TC regimen had a recurrence than women treated with TaxAC:
- 179 women treated with TC had a recurrence
- 121 women treated with TaxAC had a recurrence
This difference was statistically significant, which means that it was likely due to the difference in chemotherapy regimens and not just because of chance.
Overall, 4-year invasive disease-free survival rates were:
- 90.7% for the TaxAC regimen
- 88.2% for the TC regimen
The results strongly suggest that the anthracycline regimen is slightly better than the regimen without an anthracycline for women diagnosed with early-stage, HER2-negative breast cancer with a high risk of recurrence."
- For women with triple-negative disease (hormone-receptor-negative and HER2-negative) with no cancer in the lymph nodes, the TaxAC regimen reduced recurrence risk by 2.5% more than the TC regimen.
- For women with triple-negative disease with one to three positive nodes, the TaxAC regimen reduced recurrence risk by 10.9% more than the TC regimen.
- For women with triple-negative disease with four or more positive nodes or women with triple-negative disease with one or more positive nodes, the TaxAC regimen reduced recurrence risk by about 11% more than the TC regimen.