Hey Kay,
My wife went on Carbo/Gem for 3 month, after Xeloda did nothing, to get her skin/chest wall mets under control. Her counts tanked and needed a transfusion. They moved her to just Gem for the next 2 months and it continued to work on her mets. To the point that she went off chemo for 3 months.
Her skin mets started to return last week and they are going to put her just on the Gem to see if it will work on its own. Because the Carbo worked so well they want to save it til my wife really needs it, she's only 34, and the are worried about her bone marrow keeping up long term.
Hope that helps.
Brandon.