CT scan this morning |
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snickers 
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Joined: Apr 28 2012 Location: Washington Status: Offline Points: 134 |
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 Posted: Apr 12 2013 at 5:50pm |
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Beth
Yipee....great news! I am so happy for you and your family. I too have middle school girl slumber parties and know how tiring (but fun) they can be. Two weeks ago I had a neighbor involved scavenger hunt and I am not sure who enjoyed it more...the neighbors or the girls. Have a fantastic weekend! Snickers |
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DX 10/31/11
6/13 lung/liver mets 9/13 NED lungs,liver met part.rem 5/4/13 NED lungs&liver 11/5/13 NED lungs..liver mets back LOTS LVR METS had y90 liver trtmt mets contrld 1/3/14 num brain mets |
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btstark2003
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Joined: Apr 24 2010 Location: St. Louis area Status: Offline Points: 426 |
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Posted: Apr 25 2013 at 1:11pm |
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Hi all,
GOOD NEWS! Both Donna and I got good news from Dr Ellis yesterday.
After 6 months on a Ph1 clinical study of BAY80-6946 (PI3Ki drug) in combo with Taxol (dosed IV weekly), I have had a Complete Response (CR) to the chemo regimen! The lung mets are completely gone and I am officially in remission.
And just in time, because I have developed a dangerous side effect to the PI3Ki drug - intermittant high fevers. On Sun-Tues I had fevers of 102-103 that were not well-controlled by any meds. I had fevers on Sun-Tues for the past 4 weeks, but this week was more severe and the first time that ibuprofen wouldn't bring it down. Dr Ellis called it an idiosyncratic immune response and said it's not safe for me to continue on the study. I also have inflammatory pneumonitis visible on the CT scan (causing a dry cough and shortness of breath during physical exertion), but a short course of prednisone should fix me up.
I am so very grateful to God and my medical team and to everyone who has been praying faithfully for me and sending me positive energy.
Love to all,
Beth
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2008 Stg1 TNBC, LX, FEC+T, rads
2010 2.5cm tumor BRCA-, BMX,CMF 2011 LN mets, Gem/Carbo, surgery, rads 2012 lung mets, PI3Ki/taxo 2013 anti-PD-1 2014/15 Xeloda, IMMU-132, eribulin Aug 2015 Keytruda |
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Grateful for today
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Joined: Sep 21 2011 Location: U.S.A. Status: Offline Points: 1835 |
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Posted: Apr 25 2013 at 1:28pm |
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Beth,
Thank the good God and science. Grateful prayers of thanksgiving and gratitude with prayers for continued remission and health. Beth, you are one special person. Just as you give positive energy to us all.....may positive and healing energy resonate in your body always. With caring, positive and grateful thoughts and love and hugs, Grateful for today.............Judy ----------------- Donna, As said on Team Donna: May NED and unremarkable organs always be yours. With caring, positive and grateful thoughts and love and hugs, Grateful for today.............Judy |
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snickers
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Joined: Apr 28 2012 Location: Washington Status: Offline Points: 134 |
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Posted: Apr 25 2013 at 1:29pm |
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Wow!!!! I am so so so happy for you!!!! What a glorious day for all of us to celebrate your health and being NED!!!!
Treat yourself to something special....hot fudge sundae! |
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DX 10/31/11
6/13 lung/liver mets 9/13 NED lungs,liver met part.rem 5/4/13 NED lungs&liver 11/5/13 NED lungs..liver mets back LOTS LVR METS had y90 liver trtmt mets contrld 1/3/14 num brain mets |
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TriplePositiveGirl
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Joined: Oct 07 2010 Location: Los Angeles, CA Status: Offline Points: 667 |
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Posted: Apr 25 2013 at 2:06pm |
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Hi Beth,
To get a complete response is fantastic news! I hope this cancer stays in remission forever. I think you have been through enough already! Best Wishes to you! Lisa
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Lee21
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Joined: Dec 22 2011 Location: Michigan Status: Offline Points: 752 |
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Posted: Apr 25 2013 at 2:34pm |
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Beth,
That is awesome news and very happy for you. I am glad to hear that for us TNBCers, there may be an effective new drug. Lee |
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12/9/11 @59,IDC,grade3, TNBC,3cm(MRI),SLNB0,stage IIA, BRCA1 variant
1/30/12 DD AC-T, 6/7/12 Lumpectomy, ypT1b(0.8 cm), 7/9/12 Rads x 30 11/9/12, clinical trial cisplatin/rucaparib, cisplatin-only arm |
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Boo
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Joined: Feb 05 2012 Location: canada Status: Offline Points: 171 |
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Posted: Apr 25 2013 at 2:39pm |
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Beth fantastic news !!!!! the steroids will fix up the pnuemonitis. Many more NEDS on that bottom line. Celebrate. Love Anne
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dx 12/2010 age 50 TNBC 12 X 9 cm tumor 1 node, 3 X FEC 9 X Doxitaxol with concurrent rads - 2X3 cm residual tumor 20/1/12 mets in lungs METMAB trial May 7 to Oct. 21, CHK1 /Gem trial 26/12/12 fails
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debB
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Joined: Sep 14 2011 Location: Central Illinoi Status: Offline Points: 692 |
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Posted: Apr 25 2013 at 3:16pm |
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Beth,
Oh my GOSH! I was getting so nervous when you hadn't posted. I kept checking knowing that you and Donna were both going yesterday. CR is the most AMAZING news!!!! I can not even imagine how estatic you must feel right now. And probably nervous as heck heading into it with the symptoms. Absolutely incredible. And to have a drug that is looking promising is pretty fantastic too! Love seeing NED at the bottom of your post! SO happy for you!!!!!! Deb |
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Dx 4/29/11, 46 yrs old, 3.9 cm tumor, Stg 2 Grade 3 chemo 4 rounds DD AC, 12 weekly taxol, finish. Lumpectomy, 2mm residual tumor. 37 rounds rads completed. Cisplatin/PARP trial
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MarissaK
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Joined: Jan 06 2013 Location: Northern Cali Status: Offline Points: 84 |
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Posted: Apr 25 2013 at 4:04pm |
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Beth,
Congratulations!! So happy to hear this wonderful news. Hope you treat yourself to something fun this weekend to celebrate.
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DX 5/18/12 at age 34. Stage IIIC IDC TNBC, grade 3, 3 cm (multiregional nodal involvement). DD ACT complete 9/5/12. BMX 10/15/12, ALND: 0/12 nodes. pCR. Rads x 25 + 3 boosts completed 2/6/13. BRCA neg
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Charlene
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Joined: Aug 14 2010 Location: Atlanta, GA Status: Offline Points: 613 |
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Posted: Apr 25 2013 at 5:14pm |
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Beth,
What wonderful news! I am so happy for you! Remission is a great place to be. Charlene
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DX 3/10 @59 ILC/TNBC
Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads 3/14:NED |
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sabinecalifornia
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Joined: Aug 31 2011 Location: Corona, CA Status: Offline Points: 152 |
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Posted: Apr 25 2013 at 5:24pm |
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Beth, Congratulations, I hope this is the wonder drug for all of us. May you be NED forever! I hope you will celebrate the terrific news. have a great weekend Sabine
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DX TNBC 7/11 @ age 50, Stage 2A Grade 3, 1/19, LE/AD 8/11, BRCA1/2 neg.,
4 A/C, 10 Taxol, 2 Abraxane due to allerg. react. to Taxol, fin 3/12. 33 Rads 6/12. NED CT 8/12, 10/13, 10/14 |
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bottkota
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Joined: Aug 20 2011 Location: South Dakota Status: Offline Points: 122 |
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Posted: Apr 25 2013 at 6:56pm |
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AWESOME NEWS!!!!! Love reading posts like this!
Cathi |
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Stg 2A 4/2005 TN IDC
Stg 4 11/2009 TN 11/09-09/10Gem/Abrax/Avastin 11/10-12/12 Gem/Carbo/Inipirib 01/13-09/13 Iniparib alone 09/13-03/14 Gemzar/carbo 04/14-present veliparib (PARP) |
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123Donna
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Joined: Aug 24 2009 Location: St. Louis, MO Status: Offline Points: 13510 |
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Posted: Apr 25 2013 at 7:18pm |
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Beth,
Your good news has me still smiling today! I was worried about you when I heard about the fever. To find out you are in remission and no lung mets is nothing short of a miracle. I'm doing the "happy dance" for you friend. Your upbeat attitude and caring for others while you battled mets, is remarkable. Now you need to plan that dream family vacation and celebrate! Hugs, Donna PS: We need to plan another dinner with the TNBC gals to celebrate the good news!
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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15 |
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dmwolf
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Joined: Jan 22 2009 Location: Berkeley, CA Status: Offline Points: 3619 |
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Posted: Apr 25 2013 at 7:43pm |
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Beth, fantastic news!! I am SO happy for you!
yay yippee yahoo!!!!!! Wow! love, d |
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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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dmwolf
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Joined: Jan 22 2009 Location: Berkeley, CA Status: Offline Points: 3619 |
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Posted: Apr 25 2013 at 7:51pm |
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Don't be too sad about the fever. The immune response causing the fever is probably the same one that wiped out your cancer. If this hyperactivation of immunity is 'remembered' in your adaptive immune system, you might very well be cured. Permanently.
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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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dmwolf
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Joined: Jan 22 2009 Location: Berkeley, CA Status: Offline Points: 3619 |
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Posted: Apr 25 2013 at 7:56pm |
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(Something like this accounts for several stage IV cures on this board. There is a theme of the development of autoimmune disorders like sjoegren's or dermatomocytis coinciding with permanent disappearance of metastatic disease.)
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DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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Lillie
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Joined: Jul 10 2009 Location: Eastern NC Status: Offline Points: 3616 |
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Posted: Apr 25 2013 at 9:23pm |
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Dear Beth,
To keep on pushing through while having the side effects shows the rest of us what a fighter you are. Words cannot convey how happy I am for you. You have shown us that we "should never give up". Thank you for the Spirit and Hope you give to so many on this site.
God Bless,
Lillie Edited by Lillie - Apr 25 2013 at 9:24pm |
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Dx 6/06 age 65,IDC-TNBC
Stage IIb,Gr3,2cm,BRCA- 6/06 L/Mast/w/SNB,1of3 Nodes+ 6/06 Axl. 9 nodes- 8/8 thru 11/15 Chemo (Clin-Trial) DD A/Cx4 -- DD taxol+gemzar x4 No Rads. No RECON - 11/2018-12 yrs NED |
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btstark2003
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Joined: Apr 24 2010 Location: St. Louis area Status: Offline Points: 426 |
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Posted: Apr 26 2013 at 1:51am |
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Thanks so much everybody! I can feel the love!
Denise, I have been thinking that the hyperimmune response occurring just as the last of the mets disappeared seems like a bit too much of a coincidence, so I like your theory a lot. Especially the permanent remission bit. I will believe that and hang on to it when I have doubts. Thank you! Ever since I developed mets I have thought that in order to be cured, my immune system has to somehow learn or be trained to recognize the stray TNBC cells that chemo didnt kill as foreign and attack them, but I couldn't really visualize before exactly how it could happen. And now I will be on the lookout for some autoimmune disorder. So far I have the inflammatory pneumonitis...and the fever isn't quite gone yet but is low- grade now. You people are all treasures, who each have special gifts that you continue to share with me. I am so blessed. Still doing the happy dance!!! Beth |
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2008 Stg1 TNBC, LX, FEC+T, rads
2010 2.5cm tumor BRCA-, BMX,CMF 2011 LN mets, Gem/Carbo, surgery, rads 2012 lung mets, PI3Ki/taxo 2013 anti-PD-1 2014/15 Xeloda, IMMU-132, eribulin Aug 2015 Keytruda |
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Gabj
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Joined: Mar 22 2013 Location: Australia Status: Offline Points: 12 |
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Posted: Apr 26 2013 at 4:47am |
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Great news! What a wonderful word - remission
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Wade
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Joined: May 15 2011 Location: SE Michigan Status: Offline Points: 108 |
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Posted: Apr 26 2013 at 8:18am |
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Beth,
I loved reading that you had such a great response to treatment! Cheers to you, and to a complete response. Wade
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Wife DX 5/2011@52 2.5x3.1cm;6/2011 DD A/C 4x,Abraxane 4x; Lumpectomy, SN biopsy 10/2011; 10/27/2011 NED; Rads start 11-22-2011, Rads fin 1-11-2012; 10-2013 NED; 07-18-2014 NED; November 2018 NED
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