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Cryoablation

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Canapoli View Drop Down
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    Posted: Sep 02 2017 at 12:34pm
Has anyone heard of or experiences cryoablation (cryotherapy) for TNBC?
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mainsailset View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote mainsailset Quote  Post ReplyReply Direct Link To This Post Posted: Sep 03 2017 at 11:12am
I just googled this for TNeg
https://amandafoxcroft.com/writing-samples/put-it-on-ice-this-freezing-technique-is-a-promising-cancer-treatment/

From the article:
..."This is partly attributed to the fact that TNBC produces a certain cytokine (cell signaling protein) called interleukin-6 that inhibits T-cell response in the tumor microenvironment. Because of this the immune system becomes incapable of addresses the cancer cells.

However, new cryoablation research shows promise in treating this type of breast cancer.

One study, published in 2015 in the journal OnoImmunology, tested the use of cryoablation combined with Meriva, a patented formulation of curcumin and soy lecithin that allows for greater bioavailability, on mice with metastatic breast cancer.

Researchers performed cryoablation on the tumor and then followed up with an injection of Meriva into the tumor.

The researchers discovered this combination activated certain T-cells to multiple tumor-associated antigens (foreign bodies that prompt the immune system to respond). This resulted in a near complete reduction of primary tumors and lung metastases.

According to the study, “the survival rate in the group of cryoablation plus Meriva was significantly improved compared to all control groups” (Meriva alone, cryoablation alone or groups receiving saline control).(6)

For example, 58 days after treatment, mice receiving only cryoablation developed metastases in the lungs, while those that received cryoablation plus Meriva were free of metastases.


Edited by mainsailset - Sep 03 2017 at 11:14am
dx 7/08 TN 14x6.5x5.5 cm tumor

3 Lymph nodes involved, Taxol/Sunitab+AC, 5/09 dbl masectomy, path 2mm tumor removed, lymphs all clear, RAD 32 finished 9/11/09. 9/28 CT clear 10/18/10 CT clear
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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Sep 04 2017 at 8:09pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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