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Combining a P13K W/Parp Inhibitor For brca 1 BC

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    Posted: Nov 15 2012 at 4:47pm
http://m.cancerdiscovery.aacrjournals.org/content/2/11/1048.long
Significance: Current treatment options for triple-negative breast cancer are limited to chemotherapeutic regimens that have considerable toxicity and are not curative. We report here that the combination of a PI3K inhibitor with a PARP inhibitor provides in vivo synergy for treatment of an endogenous mouse model for BRCA1-related breast cancers, making this a candidate combination to be tested in human clinical trials.
Stage 2 2003
Stage 1 2007
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