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James123 View Drop Down
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    Posted: Feb 23 2019 at 1:57pm
I am currently in Radiation after 6 months of Chemo then surgery didnít have complete response. Radiation redid scans and is concerned about 2 enlarged lymph nodes and she plans to Radiate the are so I will get a total of 34 radiation treatments 

I was referred to a clinical trial xeloda vs Carbo at Vanderbilt university and I met with them and they are evaluating to see if I qualify.

My radiation oncologist is recommending to start The Xeloda while on radiation because she is concerned about the nodes the problem is that if I start that it will disqualify me for the trial.  The trial MO believes my TNBC is Basal like because she says 70% of TNBC is Basal like

Any thoughts 
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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 26 2019 at 8:12am
James123,

This is a hard decision.  Is this the trial your MO is suggesting for you?  It's a Phase 3 trial and while they haven't posted any results, maybe your MO has some additional information she/he can share with you.

Platinum Based Chemotherapy or Capecitabine in Treating Patients With Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Chemotherapy
ClinicalTrials.gov Identifier: NCT02445391

https://clinicaltrials.gov/ct2/show/study/NCT02445391
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Feb 26 2019 at 8:21am
James123,

Here's some information on Xeloda concurrent with radiation therapy:


Look at the conclusion of this small study (not sure how many were TNBC):


Phase 2 clinical trial (small study participants):




DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote James123 Quote  Post ReplyReply Direct Link To This Post Posted: Feb 26 2019 at 8:25am
thank you Abdul I asked dr Mayer at Vanderbilt and she said itís too soon for any preliminary results 
She said that 253 women are in the study and she says the chemotherapy are all doing well

My concern is my enlarged lymph node in my breast there are two of them 

My radiation oncologist wasnít concerned initially until she compared my recent MRI TO MRI from November and she said it was enlarged then.  Sheís says 50 /50 it could be cancer or could not

The MOat Vanderbilt thinks itís reactive

My radiation oncologist said she can start the xeloda while on radiation but it would disqualify me for the trial 


Itís s tough decision and Iím
Praying about it 
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Post Options Post Options   Thanks (0) Thanks(0)   Quote James123 Quote  Post ReplyReply Direct Link To This Post Posted: Feb 26 2019 at 8:34am
and yes that is the study 
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