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    Posted: May 10 2011 at 2:50pm
Several survivors relate being treated with adriamycin. My docs at UCLA and here in Las Vegas tell me that recent research indicates that it is not successful and does pose greater risks than the other toxic mixes that I am getting (cytoxane and dosetaxel). Any input on this?

Also: Here's a May 5 article on TNBC research....

http://www.sciencedaily.com/releases/2011/05/110505083228.htm
57 years old, mother of two daughters. 5/09 lumpectomy, rad; 3/11 C/T 6X, clear scans; 9/11 bilateral/lymph nodes surgery, NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Lillie Quote  Post ReplyReply Direct Link To This Post Posted: May 10 2011 at 3:57pm
Dear Horse Lover,
I had adriamycin and I am glad I did. I felt as though I had taken advantage of all that was offered to me almost 5 years ago.

I do realize that it can cause heart problems. I had a muga-scan prior to treatment to see if my heart was strong enough to do adriamycin. It was, and I did. I also had a muga-scan after treatment ended to check the status of my heart.

I can't tell from your signature, but it sounds as though you are stage III and taking cytoxin and taxol or taxatere. If I were you, I would be as agressive with treatment as I could be.

So far I have not had a recurrence, but I could. But I've also had almost 5 years cancer free. It's worth the risk, if your body is strong enough.

Just my humble opinion.

God Bless,
Lillie
Dx 6/06 age 65,IDC-TNBC
Stage IIb,Gr3,2cm,BRCA-
6/06 L/Mast/w/SNB,1of3 Nodes+
6/06 Axl. 9 nodes-
8/8 thru 11/15 Chemo (Clin-Trial) DD A/Cx4 -- DD taxol+gemzar x4
No Rads.
No RECON - 11/2015-9 yrs NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote dmwolf Quote  Post ReplyReply Direct Link To This Post Posted: May 10 2011 at 4:29pm
Hi,

Adria is more cardiotoxic than cytoxan or taxol, but it also works well in about 30% of TNs.  At this point, I wouldn't leave it out of treatment unless the cancer was caught early at stage I.   Between the adria and the taxane, you are much more likely to have a good response than with either of them alone.

d

DX 2/08@43 stg II IDC; gr2,0 nodes. Neoadj chemo, first ACx2 (fail) then CarboTaxotereX6(better). Lump, Rads done 11/08; Clodronate. False alarm queen: PetCT lung & TM marker. NED. PBM w/recon 9/10.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Horse Lover Quote  Post ReplyReply Direct Link To This Post Posted: May 10 2011 at 4:33pm
Should I insist? Not sure what to do....
57 years old, mother of two daughters. 5/09 lumpectomy, rad; 3/11 C/T 6X, clear scans; 9/11 bilateral/lymph nodes surgery, NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Horse Lover Quote  Post ReplyReply Direct Link To This Post Posted: May 10 2011 at 4:37pm
What is a muga-scan, please?
57 years old, mother of two daughters. 5/09 lumpectomy, rad; 3/11 C/T 6X, clear scans; 9/11 bilateral/lymph nodes surgery, NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote conniec Quote  Post ReplyReply Direct Link To This Post Posted: May 10 2011 at 5:42pm
Hi HL,
I also had a muga scan. A dye is injected intravenously and then you go into a scanner that shows your heart function.  I think it takes 10 minutes.  It's painless except for the needle prick.
Connie
Age 40,
Felt lump 8/20/10
Lumpectomy 9/7
DX 1.5 tumor stg I 9/13 margin not clear
Double MX w/ expanders 10/8
Final tumor size 1.7, 0/3 + nodes
AC-T chemo 11/8 - 2/21
TE/implant exchange 3/29

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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 10 2011 at 6:47pm
Horse Lover,

Was your recurrence Stage 3?  I agree with Denise that if anything more than Stage 1 Adriamycin should be considered.  Can you get a second opinion regarding treatment?  Wishing you the best!

Donna
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Horse Lover Quote  Post ReplyReply Direct Link To This Post Posted: May 11 2011 at 8:44pm
Hmm. I did get a second opinion. Sounds like I might need a third! My recurrence in stage 3: lymph nodes, chest wall, and breast (3 cm).

Has anyone had the Adriamycin recently? Were the side effects serious?

57 years old, mother of two daughters. 5/09 lumpectomy, rad; 3/11 C/T 6X, clear scans; 9/11 bilateral/lymph nodes surgery, NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 11 2011 at 8:55pm
HL,

Have you seen this thread Denise posted about an important new study?

http://forum.tnbcfoundation.org/attention-newbies-important-new-chemo-study_topic7771_page1.html
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote TracyAMac Quote  Post ReplyReply Direct Link To This Post Posted: May 11 2011 at 9:46pm
Dear Horse Lover

I am attaching a summary of a large long term study I posted a while ago  that  may be what your UCLA docs are referring to. It gave some reassurance to those of us who did not receive "A" &TC.  I couldn't have Adria. last year because I recieved the life time limit of it 30 years ago for a prior cancer.  So I had 6 rounds of TC instead of 4.  My onc was the one who identified the study to me however he still uses AC&T as this often seems to be a common protocol. As Lillie said, you want to throw everything you can at a TN situation. 

My experience with Adria. was a long time ago but from reading other posts here some of the side effects haven't changed  e.g. nausea, mouth sores and as the article and other posts identify, there are potential cardio issues

http://jco.ascopubs.org/content/24/34/5381.abstract

Tracy in Toronto

TN&non-TN tumors April/10 Gr3&2;1 metaplastic
Rmast.1/9 nodes w/isolated t.cells
Taxotere&Cytoxan x6
Bone cancer 1980 age17;surgery&chemo AC+Methotrexate
BRCA-ve
On hormone therapy & Metformin Trial
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 11 2011 at 9:50pm
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote TracyAMac Quote  Post ReplyReply Direct Link To This Post Posted: May 11 2011 at 9:54pm
thank you again Donna!!! One of these days I must figure out how to do this on this forum...I can do it on my e-mails but not when on this site!!! 

Tracy in Toronto
TN&non-TN tumors April/10 Gr3&2;1 metaplastic
Rmast.1/9 nodes w/isolated t.cells
Taxotere&Cytoxan x6
Bone cancer 1980 age17;surgery&chemo AC+Methotrexate
BRCA-ve
On hormone therapy & Metformin Trial
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Horse Lover Quote  Post ReplyReply Direct Link To This Post Posted: May 12 2011 at 6:37am
Thanks so much! I will discuss with doc later today when I see her! I appreciate the information!
57 years old, mother of two daughters. 5/09 lumpectomy, rad; 3/11 C/T 6X, clear scans; 9/11 bilateral/lymph nodes surgery, NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: May 12 2011 at 7:43am
HL,

Wishing you the best on your upcoming appointment today with your onc.  Keep us posted on what you find out and decide to do.

Donna


Edited by 123Donna - May 12 2011 at 10:39am
DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Momof2NJ Quote  Post ReplyReply Direct Link To This Post Posted: May 12 2011 at 9:58am
I did 4 rounds of Adriamycin in Nov/Dec last year for my TN recurrence. My original diagnosis was back in 2008 and it was stage 1, grade 3 TN.  I had Cytoxan and Taxotere for that.  I had a recurrence in september of 2010.  Given the size of my original tumor which was 1.2 cm and the fact that I had multicentric IDC micro tumors in BOTH breasts, protocol was to only to C&T.  In retrospect, I often wonder if I had done adriamycin then if I would have been spared the recurrence.
 
Adriamycin is a harsh drug.  Some women get thru it easily with minimal side effects.  I wasn't one of those.  It did make me very nauseous and no drugs prescribed helped....I tried them all, but I think i was just one of the  unlucky ones.  When I did T&C, Emend and Zofran were great and I was never sick.  The only thing that helped me during adriamycin was medicinal marijuana...it's legal in NJ.  (and this is the first time I've admitted to using med mj in this forum...go me!)
 
But...here I am today...I finished adriamycin, did 3 rounds of taxol and was then switched to Abraxane because I began to get severe neuropathy from the taxol.  Abraxane was extremely kind to me and it left me tired, but I could function and take care of my children.  I'm almost half way thru my radiation treatments (#11 of 38 today).
 
I remember posting here when I was sick as a dog on adriamycin and was considering telling my doctor I wanted to stop.  The wonderful and amazing folks here talked me off the ledge with care and compassion and I finished.  Another reason why I forged on was because of potential trial drugs that I hopefully won't need someday in the future.  Alot of clinical trials have criteria where you must be treated with the "standard" protocol" (adria being one of the standards) in order to qualify for trials with new drugs. 
 
God willing I will remain NED after radiation....I know I take comfort in knowing I won't have any "what if" moments.
 
I don't tell you my story to dissuade you.  I tell it to let you know that you can be stronger than you ever imagined possible....you CAN do it.  Chemo is hard as we can ALL attest to.  But you do it and move forward.  My motivation is my 6 and 9 year old.  I lost my mother at age 9, she was 51, to ovarian cancer and lost my sister to breast cancer when she was only 42.  My children WILL have their mother around and not go thru childhood like I did.  Failure is NOT an option for me.
 
Feeling philosopical today :)
 
love to all,
mary ellen
2008 BRCA 1+ dx stg 1,gr 3 IDC triple neg. BM w/ recon. CT x 4. Prophy TAH 2007. Recurrence 9/13/10. 10/5/10 tumor excised. ACx4, Taxol x3, abraxane x 9. 38 rads. 7/11 NED!!!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Horse Lover Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2011 at 11:32am
I want to see NED after my name, too!!! So many people that I meet just tell me about the horror stories of those that did not survive. Argh. Again, my doc did not want me to take the Andro, and I am not "qualified" for any clinical studies. The 3.1 cm has gone down to 1.3, and there were no tumors evident in my chest wall and axcilla on the MRI last week, which is good news. Has anyone seen that email supposedly from Johns Hopkins on cancer, and is any of that valid? I am hesitant to include it in the posting, since I do not want to add any mis-information, but it basically says that you can control cancer through diet. Any thoughts...?



57 years old, mother of two daughters. 5/09 lumpectomy, rad; 3/11 C/T 6X, clear scans; 9/11 bilateral/lymph nodes surgery, NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Charlene Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2011 at 11:57am

You might want to check out lbbc.org or hormonenegativeblogspot.com.  There were two recent teleconferences about TNBC and diet and exercise were mentioned in both.  You can listen to the actual programs on lbbc.org or read a summary at the other site.  Basically what was said was that the "anti-cancer diet" is not much different from what is recommended for everyone.  Good for overall health, which may play a role, but so far no actual proof that they prevent recurrence.  Best wishes to you as you complete your treatment and get to NED!

Charlene 
DX 3/10 @59 ILC/TNBC
Stage 1, Grade 2, Multifocal; Lumpectomy/re-excision
SNB 0/4 nodes, BRCA-; Taxotere/Cytoxan X4, 30 rads
3/14:NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Horse Lover Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2011 at 12:56pm
Thanks! I appreciate the resource and the encouragement!
57 years old, mother of two daughters. 5/09 lumpectomy, rad; 3/11 C/T 6X, clear scans; 9/11 bilateral/lymph nodes surgery, NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Lillie Quote  Post ReplyReply Direct Link To This Post Posted: May 16 2011 at 1:25pm
Hi Horse Lover,
I do believe our diet plays a big part in so many of our health issues; diabetes, cholesterol, heart disease, obesity, cancer, etc. I will agree with Charlene in that (concerning cancer recurrence) "once the horse is out of the barn door" it (may be) too late to close the gate. I do believe it is in our favor at all times to be diet conscious. (I wish I could claim to do this as I should, but I can't).....

Good luck with your treatments. I'm praying that your tumor will shrink into oblivion and you will be "dancing with that handsome NED" in the near future.

God Bless,
Lillie
Dx 6/06 age 65,IDC-TNBC
Stage IIb,Gr3,2cm,BRCA-
6/06 L/Mast/w/SNB,1of3 Nodes+
6/06 Axl. 9 nodes-
8/8 thru 11/15 Chemo (Clin-Trial) DD A/Cx4 -- DD taxol+gemzar x4
No Rads.
No RECON - 11/2015-9 yrs NED
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Horse Lover Quote  Post ReplyReply Direct Link To This Post Posted: May 18 2011 at 3:42pm
Thanks, Lillie, and everyone else out there! I am thankful for you, for your thoughts, for your sharing, for your bravery, for your caring, for your reaching out, for all of it -- the good, the bad, and the ugly of TNBC. I love you all; thanks for your input and kind thoughts! Going in for Round 3 tomorrow. Then I'll be 50% done...then onward to surgery. 
57 years old, mother of two daughters. 5/09 lumpectomy, rad; 3/11 C/T 6X, clear scans; 9/11 bilateral/lymph nodes surgery, NED
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