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Adriamycin, Cyclophosphamide, and then Taxol

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Asovey View Drop Down
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    Posted: Dec 09 2017 at 1:07pm
I am at a stage 3 right now and the plan is to start neoadjuvent chemo with Adriamycin and Cyclophosphamide, and then finish with Taxol.  I am assuming it will be dose dense, but not sure.  These drugs could change as I am having a second opinion at Slone Kettering on the 19th.  Has anyone had chemo with any of the above?  side effects?
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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Dec 09 2017 at 2:40pm
Asovey,

What you are getting is the standard chemo most women get.  There was a study that adding Carboplatin to Taxol improves pCR.  You might ask about adding Carbo to your chemo regimen.

Please read through this thread:



DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Post Options Post Options   Thanks (1) Thanks(1)   Quote tapimb Quote  Post ReplyReply Direct Link To This Post Posted: Dec 12 2017 at 9:23pm
I had 6 dose dense Adriamycin + Cyclophosphamide (Cytoxan) and 6 dose dense Taxol treatments in 2007/2008. AC was more difficult because of the fatigue and the neulasta injection (white blood cell booster) gave me some general bone pain for a few days after. I tolerated the Taxol very well. The only side effect I noticed with Taxol was some peripheral neuropathy (fingers and toes tingling) but this disappeared after treatment.
A little tip: To fight the fatigue, make sure you stay active, eat a well balanced diet, and drink plenty of water/juice. 
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Asovey View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Asovey Quote  Post ReplyReply Direct Link To This Post Posted: Dec 13 2017 at 12:39pm
Thank you for this info. I am hoping to tolerate the chemo well. I should start the week of Christmas.
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Post Options Post Options   Thanks (1) Thanks(1)   Quote lsteuer Quote  Post ReplyReply Direct Link To This Post Posted: Dec 13 2017 at 4:47pm
I just started the 1st of 4 cycles of a-c and will finished with 12 weeks of taxol. Yesterday I had a second opinion at Stanford Hospital Breast Cancer clinic and they agreed with this course of action. So far things are going well just a little ‘queezy’ but I think this is the new normal for a bit.
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Lucky22 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 14 2017 at 10:21pm
I have my last Taxol next week - yay! I was diagnosed at 1b because of a cancerous intramammary node - don’t goggle that! I was devastated, but got my head straight and understand my prognosis is good. Sometimes doing internet research is a bad idea.
I had a tough time on AC - but my nausea seemed worst than others. I won’t lie, it can be a real bummer and emotional. Taxol for me has been so much easier. I get some bloody noses. In the beginning had a lot of muscle and bone pain but realized it was heartburn and Pepcid helped a lot. I believe fatigue with this is accumulative - I am now a hardcore napper . Drinking a lot of water is a must as is exercise. I can’t believe it is almost over. I’m both excited and scared - but more relieved and ready to move on.
One serious tidbit of advice - don’t stop living. Enjoy every day.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Motherofall6 Quote  Post ReplyReply Direct Link To This Post Posted: Dec 23 2017 at 7:56pm
Port goes in Thursday and my first chemo Jan 3, I’m getting 4 a/c every other week then 12 taxol
diagnosed 10/27/2017
triple negative breast cancer
stage 1 grade 3
lumpectomy 11/10/2017
radiation
chemo 1/3/2018
A/C x4 then taxol x 12
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Asovey View Drop Down
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Asovey Quote  Post ReplyReply Direct Link To This Post Posted: Dec 24 2017 at 1:36pm
Getting your port in is not a big deal. I had mine put in about three weeks ago. A bit sore at site for a couple days, but now I even forget it is there. Hope to start chemo next week.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Tlrtoffee Quote  Post ReplyReply Direct Link To This Post Posted: Dec 28 2017 at 2:43am
Hello. I noticed u had a second opinion at Stanford. I live in Northern California and I am in search of a reputable oncologist and breast surgeon who is familiar with tnbc and has knowledge of cutting edge treatments for those of us who have tnbc. I was just diagnosed and stage 2. UCSF has long wait time to get in. Do u know of a tnbc specialist also? Thank you.

Edited by Tlrtoffee - Dec 28 2017 at 2:52am
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123Donna View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote 123Donna Quote  Post ReplyReply Direct Link To This Post Posted: Dec 28 2017 at 11:35am
Tirtoffee,

Please contact Steve (SagePatientAdvocates).  He's a patient advocate and has helped many of us get appointments sooner.  His member name is SagePatientAdvocates.  You can find him by going to "members" and searching for his name.  You can then send him a private message with your contact information.  He's pretty responsive and will hopefully get in touch with you quickly.

Donna


DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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Asovey View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Asovey Quote  Post ReplyReply Direct Link To This Post Posted: Dec 28 2017 at 12:20pm
You might want to check with Slone Kettering in NYC to get an appointment with Dr. Tiffany Traina.  She is amazing and a specialist in tnbc. Here is her contact info: Address1275 York Ave, New York, NY 10065
Phone(646) 888-5209

I live in Michigan and it was a quick plane ride there and back.  We easily did it in two days.  I took the plan that was developed by our local cancer center and Dr. Traina made some changes.  She is great at working with other physicians with out of town patients.  I go back to her in six months.  Hopefully chemo and surgery will be done by then.

Ann
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Kellyless Quote  Post ReplyReply Direct Link To This Post Posted: Dec 28 2017 at 2:06pm
I second the suggestion for contacting Steve.  He got me in to a wonderful doc at MD Anderson in time for a second opinion before I had to start chemo, which changed my treatment.  There was a 6 month wait without his help! It changed my treatment plan and just may have saved my life.
To avoid peripheral neuropathy from Taxol ask to ice your hands and feet during the transfusions.  I've done it thru 2 courses of treatment and I KNOW it saved me from the worst of it.  The actual Taxol infusion is under 2 hours, so the ice is NBD.  
IDC, 2.2 cm, Stage IIb,lumpectomy 1/30/09 ACx4,Tx4 36 rads
6/1/17 Local recurrence same breast, same spot 1.8cm Carb.4x every 3 wks, Taxol 12x once wk. Dbl Mast. PCR!! Reconstruction fail, NED!
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