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Abraxane and Carboplatin Frontline Therapy

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    Posted: Jan 31 2017 at 10:35pm
The combination of Abraxane (nab-paclitaxel) and carboplatin reduced the risk of progression or death by 40 percent compared with two other chemotherapy combinations as a frontline therapy for patients with metastatic triple-negative breast cancer (TNBC), according to recent findings from the phase 2 tnAcity study presented at the 2016 San Antonio Breast Cancer Symposium. The median progression-free survival (PFS) was 7.4 months with Abraxane plus carboplatin compared with 5.4 months for Abraxane plus gemcitabine and six months for gemcitabine plus carboplatin. The 12-month PFS rate was 27 percent with Abraxane/carboplatin compared with 13 percent and 11 percent for Abraxane/gemcitabine and gemcitabine/carboplatin, respectively. "I think it's an exciting study because there's such a role for doublet therapy, particularly in the triple-negative population. There's a lot of controversy between sequential single-agent or doublet therapy," said lead investigator Denise A. Yardley, M.D., senior investigator at the Sarah Cannon Research Institute. "The Abraxane/carboplatin arm in this phase 2 study came out demonstrating the ideal efficacy pattern for the triple-negative population."

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DX IDC TNBC 6/09 age 49, Stage 1,Grade 3, 1.5cm,0/5Nodes,KI-67 48%,BRCA-,6/09bi-mx, recon, T/C X4(9/09)
11/10 Recur IM node, Gem,Carb,Iniparib 12/10,MRI NED 2/11,IMRT Radsx40,CT NED11/13,MRI NED3/15

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